Airborne SARS-CoV-2 transmission represents a significant route for possible human infection that is not yet fully understood. Viruses in droplets and aerosols are difficult to detect because they are typically present in low amounts. In addition, the current techniques used, such as RT-PCR and virus culturing, require large amounts of time to get results. Biosensor technology can provide rapid, handheld, and point-of-care systems that can identify virus presence quickly and accurately. This paper reviews the background of airborne virus transmission and the characteristics of SARS-CoV-2, its relative risk for transmission even at distances greater than the currently suggested 6 feet (or 2 m) physical distancing. Publications on biosensor technology that may be applied to the detection of airborne SARS-CoV-2 and other respiratory viruses are also summarized. Based on the current research we believe that there is a pressing need for continued research into handheld and rapid methods for sensitive collection and detection of airborne viruses. We propose a paper-based microfluidic chip and immunofluorescence assay as one method that could be investigated as a low-cost and portable option.

中文翻译：

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生物传感器检测空气传播的呼吸道病毒，例如 SARS-CoV-2。


SARS-CoV-2 空气传播是人类可能感染的一个重要途径，但目前尚未完全了解。飞沫和气溶胶中的病毒很难检测，因为它们通常含量较低。此外，目前使用的技术，例如RT-PCR和病毒培养，需要大量时间才能得到结果。生物传感器技术可以提供快速、手持式和即时护理系统，可以快速、准确地识别病毒的存在。本文回顾了空气传播病毒传播的背景和 SARS-CoV-2 的特征，以及即使在超过目前建议的 6 英尺（或 2 m）物理距离的情况下其传播的相对风险。还总结了可用于检测空气传播的 SARS-CoV-2 和其他呼吸道病毒的生物传感器技术的出版物。根据目前的研究，我们认为迫切需要继续研究用于灵敏收集和检测空气传播病毒的手持式快速方法。我们提出一种纸基微流控芯片和免疫荧光测定作为一种方法，可以作为一种低成本和便携式选择进行研究。