The prevalence, incidence, and progression of radiographic thumb base osteoarthritis in a population-based cohort: the Rotterdam Study,Osteoarthritis and Cartilage

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The prevalence, incidence, and progression of radiographic thumb base osteoarthritis in a population-based cohort: the Rotterdam Study
Osteoarthritis and Cartilage ( IF 7.2 ) Pub Date : 2022-01-20 , DOI: 10.1016/j.joca.2022.01.003
J S Teunissen ₁ , R M Wouters ₂ , S M A Bierma-Zeintra ₃ , J B J van Meurs ₄ , T A R Schreuders ₅ , J M Zuidam ₅ , R W Selles ₆

Affiliation

Department of Plastic, Reconstructive and Hand Surgery, Erasmus MC, University Medical Centre Rotterdam, 2040, 3000 CA Rotterdam, the Netherlands; Department of Rehabilitation Medicine, Erasmus MC, University Medical Centre Rotterdam, 2040, 3000 CA Rotterdam, the Netherlands; Department of Plastic, Reconstructive, and Hand Surgery, Radboudumc, 9101, 6500 HB Nijmegen, the Netherlands.
Department of Plastic, Reconstructive and Hand Surgery, Erasmus MC, University Medical Centre Rotterdam, 2040, 3000 CA Rotterdam, the Netherlands; Department of Rehabilitation Medicine, Erasmus MC, University Medical Centre Rotterdam, 2040, 3000 CA Rotterdam, the Netherlands; Center for Hand Therapy, Handtherapie Nederland, the Netherlands.
Department of General Practice, Erasmus MC, University Medical Centre Rotterdam, 2040, 3000 CA Rotterdam, the Netherlands; Department of Orthopedic Surgery, Erasmus MC, University Medical Centre Rotterdam, 2040, 3000 CA Rotterdam, the Netherlands.
Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, 2040, 3000 CA Rotterdam, the Netherlands.
Department of Plastic, Reconstructive and Hand Surgery, Erasmus MC, University Medical Centre Rotterdam, 2040, 3000 CA Rotterdam, the Netherlands.
Department of Plastic, Reconstructive and Hand Surgery, Erasmus MC, University Medical Centre Rotterdam, 2040, 3000 CA Rotterdam, the Netherlands; Department of Rehabilitation Medicine, Erasmus MC, University Medical Centre Rotterdam, 2040, 3000 CA Rotterdam, the Netherlands.

Objective

To describe the prevalence, incidence, and progression of radiographic thumb carpometacarpal (CMC-1) and trapezioscaphoid (TS) radiographic osteoarthritis (ROA) in the general Dutch population aged ≥55y.

Design

Data were from the first and second cohort of the Rotterdam Study (1990–2005, 4–12 years follow-up, age 55+). Participants underwent bilateral radiographs at baseline (N = 7792) and follow-up (N = 3804), read for Kellgren–Lawrence (K-L) grade. ROA was defined on the joint level as K-L grade ≥2. The prevalence was assessed at baseline, incidence at follow-up in those free of ROA at baseline, and progression in those with ROA. Differences based on sex and age were evaluated using logistic regression models.

Results

At baseline, 1977 (25.3%) had CMC-1 ROA and 1133 (14.5%) TS ROA. The prevalence was higher in females for CMC-1 (aOR = 1.98 95%CI [1.77–2.21]) and TS ROA (aOR = 2.00 [1.74–2.29]) and increased for every year of age (CMC-1 ROA 1.08 [1.07–1.08]) (TS ROA 1.06 [1.05–1.07]). Most (437/512; 85.4%) incident cases of CMC-1 ROA (2994 at risk) were mild (K-L = 2), whereas most (145/167; 86,8%) incident cases of TS ROA (3311 at risk) were moderate to severe (K-L = 3/4). CMC-1 ROA progression was mostly (88/100; 88.0%) seen in the K-L 2 group at baseline, whereas that was (4/17; 23.5%) for TS ROA.

Conclusion

CMC-1 ROA and TS ROA are prevalent in the general Dutch population. While incident CMC-1 ROA was primarily mild, incident TS ROA was more often moderate to severe. CMC-1 ROA was a strong predictor for incident TS ROA.

中文翻译：

以人群为基础的队列中影像学拇指基部骨关节炎的患病率、发病率和进展：鹿特丹研究

客观的

描述 ≥ 55 岁的荷兰普通人群中影像学拇指腕掌骨 (CMC-1) 和梯形舟骨 (TS) 影像学骨关节炎 (ROA) 的患病率、发病率和进展。

设计

数据来自鹿特丹研究的第一和第二队列（1990-2005，4-12 年随访，55 岁以上）。参与者在基线 (N = 7792) 和随访 (N = 3804) 接受了双侧 X 光片，读取 Kellgren-Lawrence (KL) 等级。ROA 在关节水平上定义为 KL 等级≥2。评估基线时的患病率、基线时无 ROA 患者的随访发生率以及有 ROA 患者的进展情况。使用逻辑回归模型评估基于性别和年龄的差异。

结果

在基线，1977 (25.3%) 有 CMC-1 ROA 和 1133 (14.5%) TS ROA。女性 CMC-1 (aOR = 1.98 95%CI [1.77–2.21]) 和 TS ROA (aOR = 2.00 [1.74–2.29]) 的患病率较高，并且随着年龄的增长而增加 (CMC-1 ROA 1.08 [ 1.07–1.08]）（TS ROA 1.06 [1.05–1.07]）。大多数 (437/512; 85.4%) CMC-1 ROA (2994 有风险) 事件为轻度 (KL = 2)，而大多数 (145/167; 86.8%) TS ROA 事件 (3311 有风险) ) 为中度至重度 (KL = 3/4)。在基线时，KL 2 组中的 CMC-1 ROA 进展主要是（88/100；88.0%），而 TS ROA 是（4/17；23.5%）。