In this paper, we numerically and experimentally propose a novel hollow-core microstructured optical fiber (HC-MOF) biosensor for refractive index determination. The sensing mechanism of the proposed sensor is based on photonic bandgap effect and the location of transmission maxima of the fiber, which is strongly depend on the liquid analyte RI filled in the fiber core. The proposed HC-MOF biosensor demonstrates the spectral sensitivity of 5636.3 nm/RIU with a RI detection range of 1.333 to 1.3385 for different ratios of plasma in blood serum in our experimental studies. The HC-MOF proposed here can detect similar liquid analytes with RI close to 1.33. The proposed sensor with a high sensitivity, ease of operation and the possibility of real-time sensing has a strong potential for detection of liquid analytes and biomolecules with possible applications in medicine, chemistry, and biology.

中文翻译：

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基于空心微结构光纤的折射仪：数值模拟和实验研究


在本文中，我们通过数值和实验提出了一种用于折射率测定的新型空心微结构光纤（HC-MOF）生物传感器。该传感器的传感机制基于光子带隙效应和光纤传输最大值的位置，这在很大程度上取决于光纤芯中填充的液体分析物 RI。在我们的实验研究中，所提出的 HC-MOF 生物传感器对于血清中不同比例的血浆表现出 5636.3 nm/RIU 的光谱灵敏度，RI 检测范围为 1.333 至 1.3385。这里提出的 HC-MOF 可以检测 RI 接近 1.33 的类似液体分析物。所提出的传感器具有高灵敏度、易于操作和实时传感的可能性，在检测液体分析物和生物分子方面具有强大的潜力，并可能在医学、化学和生物学领域得到应用。