Peri-implant angiogenesis plays important roles in osseointegration of implants. Unfulfilling neovascularization will lead to delayed union or non-union after prosthetic implanted. In this paper, a nanostructured surface composed of TiO₂, CuO and Cu₂O was fabricated on Ti-Cu alloy using an alkali-heat treatment. The nanostructure strengthened anticorrosion but accelerated Cu ions release. Meanwhile, in vitro cells experiments proved both Cu ions release and nanostructure on the surface of Ti-Cu alloy improved the functionality of human umbilical vein endothelial cells (HUVECs) resulting in excellent pro-angiogenesis potential indicated by promoted initial adhesion and spreading, satisfied cytocompatibility, enhanced migration, improved tube formation, upregulated angiogenesis-related genes and increased VEGF protein secretion. It was suggested that the modified Ti-Cu alloy with desired angiogenesis might be a promising strategy to improve osseointegration.

种植体周围血管生成在种植体骨整合中起重要作用。未完成的新生血管形成将导致假体植入后延迟愈合或不愈合。在本文中，使用碱热处理在Ti-Cu合金上制备了由TiO ₂、CuO和Cu _{2 O组成的纳米结构表面。}纳米结构增强了防腐性，但加速了铜离子的释放。同时，体外细胞实验证明，Ti-Cu 合金表面的 Cu 离子释放和纳米结构改善了人脐静脉内皮细胞 (HUVECs) 的功能，从而产生了良好的促血管生成潜力，表现为促进初始粘附和扩散，满足细胞相容性，增强迁移，改善管形成，上调血管生成相关基因和增加 VEGF 蛋白分泌。有人提出，具有所需血管生成的改性 Ti-Cu 合金可能是改善骨整合的有前途的策略。