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Synthesis and in vitro and in vivo evaluation of manganese(III) porphyrin–dextran as a novel MRI contrast agent
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2009-10-04 , DOI: 10.1016/j.bmcl.2009.10.003 Zhi Zhang , Rui He , Kun Yan , Qian-ni Guo , Yun-guo Lu , Xu-xia Wang , Hao Lei , Zao-ying Li
中文翻译：
新型卟啉-右旋糖酐锰（III）的合成及体内外评价
更新日期：2009-10-04
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2009-10-04 , DOI: 10.1016/j.bmcl.2009.10.003 Zhi Zhang , Rui He , Kun Yan , Qian-ni Guo , Yun-guo Lu , Xu-xia Wang , Hao Lei , Zao-ying Li
5-(4-Aminophenyl)-10,15,20-tris(4-sulfonatophenyl) manganese(III) porphyrin conjugated with dextran was synthesized. Its potential of being used as a tumor-targeting magnetic resonance imaging contrast agent was evaluated in vitro and in vivo. The results demonstrated that the compound has a longitudinal relaxivity (R1) higher than Gd-DTPA, low cytotoxicity and binding specificity to tumor cell membrane.
中文翻译：
新型卟啉-右旋糖酐锰（III）的合成及体内外评价
合成了与右旋糖酐共轭的5-（4-氨基苯基）-10,15,20-三（4-磺酰基苯基）锰（III）卟啉。在体外和体内评估了其用作肿瘤靶向磁共振成像造影剂的潜力。结果表明该化合物具有比Gd-DTPA高的纵向弛豫性（R 1），低细胞毒性和对肿瘤细胞膜的结合特异性。
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