Droughts are characterized by limited water resources and extreme arid climates and have a notable influence on crop yield and food security. Therefore, evaluating the crop drought stress at a large spatiotemporal scale is important. In this study, maize planting areas in the Northeast China Plain (NECP) and North China Plain (NCP) over the past 20 years (2000–2019) were identified from the moderate resolution imaging spectroradiometer (MODIS) enhanced vegetation index, comprising 8-day time-series moving windows. The temperature vegetation drought index (TVDI) was retrieved using the MODIS normalized difference vegetation index (NDVI) and land surface temperature datasets to evaluate maize drought. Furthermore, by combining MODIS NDVI with measured meteorological data, monthly net primary productivity (NPP) was retrieved based on the Carnegie–Ames–Stanford approach (CASA) to characterize the maize biomass. Thus, the weight of drought stress in different growth stages of maize was obtained by combining the maize phenological information with TVDI and NPP. Moreover, TVDI_{drought stress} was obtained to comprehensively assess maize drought stress. Finally, we fitted TVDI_{drought stress} with NPP to establish a conceptual model for the response of maize biomass to drought stress in the NCP and NECP at a large spatiotemporal scale for the first time. The conceptual model revealed that the phenomenon of excessive moisture during maize growth was not evident (TVDI_{drought stress} < 0.375) and that most maize plants were still affected by drought stress (TVDI_{drought stress} > 0.375) in the NECP. Correspondingly, in the NCP, there was hardly any excessive moisture, and maize exhibited a certain resistance to low-intensity drought stress (TVDI_{drought stress} was approximately 0.330). However, after the drought stress exceeded the tolerance range (TVDI_{drought stress} > 0.375), the maize biomass was significantly affected by drought stress. Our findings illustrate the two response models of drought stress in the major maize producing areas of China for the first time, thereby providing new insights for preventing drought stress risk and improving maize yield on a large scale.