Background

Herbal medication has been used for thousands of years. Although synergic efficiency of compound herbal medicine to humans have been explored for years, detailed mechanisms behind this "cocktail" medication still required open for discussion.

Method

With electrochemical inspections, this feasibility study tended to decipher combined interactions of synergy and antagonism of Levodopa (L-DOPA) and tea extracts of Camellia sinensis (L.) Kuntze (green tea) and Camelliaboreali-yunnanica (black tea) extracted from different temperatures via total phenolics concentrations, DPPH free radical scavenging ability, bioelectricity-generating capability of microbial fuel cells for bioenergy expression.

Significance of findings

According to replacement series and concentration addition (CA) methods, the most significant synergistic effect was quantitatively disclosed at the ratio of L-DOPA: tea extract at 80:20. This work provided the novel means revealing synergic efficacy of herbal medicine via the perspective of bioenergy extraction for medication. The rankings of power-stimulating efficiency in DC-MFC modules were HG2 > CG2 > HR2 > CR2. The replacement-series method indicated that both L-DOPA and tea extracts did not own tendency to out-compete each other. The CA method revealed that both L-DOPA and tea extracts were dis-similar and synergistic in action of bioenergy extraction. The most promising ratio of interactive synergy is L-DOPA: tea extract at 80:20.

中文翻译：

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生物能表达对帕金森病复方中草药的协同作用：置换系列和浓度添加的方法

背景

草药已经使用了数千年。尽管复方草药对人类的协同作用已经探索多年，但这种“鸡尾酒”药物背后的详细机制仍有待讨论。

方法

通过电化学检查，该可行性研究倾向于破译左旋多巴 (L-DOPA) 与从不同温度提取的茶提取物(L.) Kuntze (绿茶) 和Camelliaboreali -yunnanica (红茶) 的协同作用和拮抗作用的组合相互作用通过总酚类浓度、DPPH 自由基清除能力、微生物燃料电池的生物发电能力来表达生物能源。

调查结果的意义

根据置换系列和浓度添加 (CA) 方法，在 L-DOPA：茶提取物的比例为 80:20 时定量揭示了最显着的协同效应。这项工作提供了从生物能源提取药物的角度揭示草药协同功效的新手段。DC-MFC 模块的功率激励效率排名为 HG2 > CG2 > HR2 > CR2。置换系列法表明，左旋多巴和茶提取物均不存在相互竞争的趋势。CA 方法表明，L-DOPA 和茶提取物在生物能源提取的作用上是不同的和协同的。交互协同作用最有希望的比例是左旋多巴：茶提取物 80:20。