Trend in Sensitivity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Serology One Year After Mild and Asymptomatic Coronavirus Disease 2019 (COVID-19): Unpacking Potential Bias in Seroprevalence Studies,Clinical Infectious Diseases

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Trend in Sensitivity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Serology One Year After Mild and Asymptomatic Coronavirus Disease 2019 (COVID-19): Unpacking Potential Bias in Seroprevalence Studies
Clinical Infectious Diseases ( IF 11.8 ) Pub Date : 2022-01-12 , DOI: 10.1093/cid/ciac020
Christopher R Bailie _{1,

2} , Yeu Yang Tseng ₃ , Louise Carolan ₄ , Martyn D Kirk ₅ , Suellen Nicholson ₆ , Annette Fox ₇ , Sheena G Sullivan ₃

Affiliation

World Health Organization (WHO) Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne VIC, Australia.
National Centre for Epidemiology and Public Health, Australian National University, Canberra Australian Capital Territory (ACT), Australia.
WHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, and Department of Infectious Disease, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne Victoria (VIC), Australia.
WHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne VIC, Australia.
National Centre for Epidemiology and Public Health, Australian National University, Canberra ACT, Australia.
Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne VIC, Australia.
WHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, and Department of Microbiology and Immunology, University of Melbourne, and Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne VIC, Australia.

A key aim of serosurveillance during the coronavirus disease 2019 (COVID-19) pandemic has been to estimate the prevalence of prior infection, by correcting crude seroprevalence against estimated test performance for polymerase chain reaction (PCR)-confirmed COVID-19. We show that poor generalizability of sensitivity estimates to some target populations may lead to substantial underestimation of case numbers.

中文翻译：

2019 年轻度和无症状冠状病毒病 (COVID-19) 一年后严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 血清学的敏感性趋势：揭示血清阳性率研究中的潜在偏差

在 2019 年冠状病毒病 (COVID-19) 大流行期间进行血清监测的一个关键目标是通过根据聚合酶链反应 (PCR) 确认的 COVID-19 的估计测试性能校正粗血清流行率来估计先前感染的流行率。我们表明，对某些目标人群的敏感性估计的普遍性较差可能导致病例数的严重低估。

更新日期：2022-01-12

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