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The Auditory P50 Gating in Mild Cognitive Impairment: A Case-Control Study
American Journal of Alzheimer's Disease and other Dementias ( IF 2.7 ) Pub Date : 2022-01-13 , DOI: 10.1177/15333175211068966
Weidong Song 1 , Xiaohui Hu 1 , Guohua Xie 2 , Wentao Lai 3 , Yang Wang 4 , Donghui Wu 2
Affiliation  

Objective: Auditory P50 gating changed might be a neurophysiological biomarker of the diagnosis of Mild Cognitive Impairment (MCI). We aimed to determine the impact of MCI in auditory P50 gating. Methods: All recruited participants completed structured questionnaires and finished auditory P50 gating measure. Results: A total of 20 MCI patients and 17 controls had been recruited. MCI patients had a significant higher reduction of P50 gating at Fz site, when compared to controls (1.21 ± .68 vs .66 ± .37, P = .00). Zero point five was the best cut off point to distinguish MCI and control of auditory P50 gating S2/S1 at Fz site. The P50 average amplitude at Pz site in MCI patients was significantly higher than controls (2.62 ± 1.20 vs 1.70 ± .74, P = .01). Conclusion: MCI patients might have impaired the ability of inhibiting the repeated stimulus.



中文翻译:


轻度认知障碍中的听觉 P50 门控:病例对照研究



目的:听觉 P50 门控改变可能是诊断轻度认知障碍 (MCI) 的神经生理学生物标志物。我们的目的是确定 MCI 对听觉 P50 门控的影响。方法:所有招募的参与者均完成了结构化问卷并完成了听觉 P50 门控测量。结果:总共招募了 20 名 MCI 患者和 17 名对照者。与对照组相比,MCI 患者 Fz 位点的 P50 门控显着降低(1.21 ± .68 vs .66 ± .37,P = .00)。零点五是区分 MCI 和 Fz 位点听觉 P50 门控 S2/S1 的控制的最佳截止点。 MCI 患者 Pz 部位的 P50 平均振幅显着高于对照组(2.62 ± 1.20 vs 1.70 ± .74,P = .01)。结论:MCI患者抑制重复刺激的能力可能受损。

更新日期:2022-01-13
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