Objective: Auditory P50 gating changed might be a neurophysiological biomarker of the diagnosis of Mild Cognitive Impairment (MCI). We aimed to determine the impact of MCI in auditory P50 gating. Methods: All recruited participants completed structured questionnaires and finished auditory P50 gating measure. Results: A total of 20 MCI patients and 17 controls had been recruited. MCI patients had a significant higher reduction of P50 gating at Fz site, when compared to controls (1.21 ± .68 vs .66 ± .37, P = .00). Zero point five was the best cut off point to distinguish MCI and control of auditory P50 gating S2/S1 at Fz site. The P50 average amplitude at Pz site in MCI patients was significantly higher than controls (2.62 ± 1.20 vs 1.70 ± .74, P = .01). Conclusion: MCI patients might have impaired the ability of inhibiting the repeated stimulus.

目的：听觉 P50 门控改变可能是诊断轻度认知障碍 (MCI) 的神经生理学生物标志物。我们的目的是确定 MCI 对听觉 P50 门控的影响。方法：所有招募的参与者均完成了结构化问卷并完成了听觉 P50 门控测量。结果：总共招募了 20 名 MCI 患者和 17 名对照者。与对照组相比，MCI 患者 Fz 位点的 P50 门控显着降低（1.21 ± .68 vs .66 ± .37，P = .00）。零点五是区分 MCI 和 Fz 位点听觉 P50 门控 S2/S1 的控制的最佳截止点。 MCI 患者 Pz 部位的 P50 平均振幅显着高于对照组（2.62 ± 1.20 vs 1.70 ± .74，P = .01）。结论：MCI患者抑制重复刺激的能力可能受损。