Innovative memory paradigms have been introduced to capture subtle memory changes in early Alzheimer’s disease (AD). We aimed to examine the associations between different indexes of the challenging Memory Binding Test (MBT) and hippocampal volume (HV) in a sample of individuals with subjective cognitive decline (SCD; n = 50), amnestic mild cognitive impairment (aMCI) due to AD (n = 31), and cognitively normal (CN) older adults (n = 29) recruited from the Czech Brain Aging Study, in contrast to traditional verbal memory tests. Both MBT free and cued recall scores in immediate and delayed recall conditions were associated with lower HV in both SCD and aMCI due to AD, whereas in traditional verbal memory tests only delayed recall scores were associated with lower HV. In SCD, the associations with lower HV in the immediate recall covered specific cued recall indexes only. In conclusion, the MBT is a promising test for detecting subtle hippocampal-associated memory decline during the predementia continuum.

引入了创新的记忆范例来捕捉早期阿尔茨海默氏病 (AD) 中细微的记忆变化。我们的目的是检查具有挑战性的记忆结合测试 (MBT) 的不同指标与主观认知下降 (SCD; n = 50)、由于以下原因导致的遗忘性轻度认知障碍 ( aMCI ) AD（n = 31）和认知正常（CN）的老年人（n= 29) 从捷克大脑老化研究中招募，与传统的语言记忆测试形成对比。在立即和延迟回忆条件下的无 MBT 和提示回忆分数都与 AD 导致的 SCD 和 aMCI 中较低的 HV 相关，而在传统的语言记忆测试中，只有延迟回忆分数与较低的 HV 相关。在 SCD 中，即时回忆中与较低 HV 的关联仅涵盖特定的线索回忆指数。总之，MBT 是一种很有前途的测试，用于检测痴呆前连续体期间与海马体相关的细微记忆衰退。