OBJECTIVE Opioid use disorder (OUD) and chronic pain frequently co-occur. Little is known about changes in pain during buprenorphine/naloxone (BUP/NX) maintenance and whether outcomes vary by pain levels. The present study examined changes in pain intensity and pain interference over 12 weeks of BUP/NX maintenance among participants with OUD and chronic pain (N = 194). Differences in outcomes were assessed during BUP/NX maintenance (Week 12) and 2 months following a BUP/NX taper (Week 24). METHOD Data from Phase 2 of the Prescription Opioid Addiction Treatment Study (POATS) were used. Two latent transition models were conducted to characterize profiles and transitions between profiles of pain intensity or pain interference (estimated separately). RESULTS Each model identified a high and low profile. In the pain interference model, the majority were classified in the low profile at baseline. In the pain intensity model, the majority were classified in the high profile at baseline. In both models, patients were more likely to remain in or transition to the low profiles by Week 12. Worse depression was associated with membership in the high pain interference profile at both timepoints. Women were more likely to be in the high pain intensity profile at baseline. Those in the high pain intensity and high pain interference profiles at Week 12 reported worse mental health quality of life (MH-QOL) at Week 12, as well as high pain intensity and high pain interference at Week 24. CONCLUSIONS For a subgroup of patients, high pain intensity and high pain interference remains unchanged during BUP/NX maintenance treatment. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

中文翻译：

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阿片类药物使用障碍和慢性疼痛患者在丁丙诺啡维持治疗期间疼痛的变化。

目标阿片类药物使用障碍 (OUD) 和慢性疼痛经常同时发生。关于丁丙诺啡/纳洛酮 (BUP/NX) 维持期间疼痛的变化以及结果是否因疼痛程度而异，我们知之甚少。本研究检查了患有 OUD 和慢性疼痛的参与者（N = 194）在 BUP/NX 维持 12 周内疼痛强度和疼痛干扰的变化。在 BUP/NX 维护期间（第 12 周）和 BUP/NX 减量后 2 个月（第 24 周）评估结果差异。方法 使用处方阿片类药物成瘾治疗研究 (POATS) 第 2 阶段的数据。进行了两个潜在的转换模型来表征疼痛强度或疼痛干扰（单独估计）的分布和分布之间的转换。结果 每个模型都确定了高调和低调。在疼痛干扰模型中，大多数人在基线时被归类为低调。在疼痛强度模型中，大多数在基线时被归类为高调。在这两种模型中，患者更有可能在第 12 周之前保持或过渡到低调。更严重的抑郁与两个时间点的高疼痛干扰谱的成员相关。女性在基线时更有可能处于高疼痛强度状态。那些在第 12 周处于高疼痛强度和高疼痛干扰特征的患者在第 12 周报告了较差的心理健康生活质量 (MH-QOL)，在第 24 周报告了高疼痛强度和高疼痛干扰。 ，高疼痛强度和高疼痛干扰在 BUP/NX 维持治疗期间保持不变。（PsycInfo 数据库记录 (c) 2022 APA，保留所有权利）。