Rationale Despite high prevalence of e-cigarette use (vaping), little is currently known regarding the health effects of secondhand nicotine vape exposure. Objective To investigate whether exposure to secondhand nicotine vape exposure is associated with adverse respiratory health symptoms among young adults. Method We investigated the effect of secondhand nicotine vape exposure on annually reported wheeze, bronchitic symptoms and shortness of breath in the prospective Southern California Children Health Study cohort. Data were collected from study participants (n=2097) with repeated annual surveys from 2014 (average age: 17.3 years) to 2019 (average age: 21.9). We used mixed effect logistic regression to evaluate the association between secondhand nicotine vape and respiratory symptoms after controlling for relevant confounders. Results Prevalence of secondhand nicotine vape increased from 11.7% to 15.6% during the study period in this population. Prevalence of wheeze, bronchitic symptoms and shortness of breath ranged from 12.3% to 14.9%, 19.4% to 26.0% and 16.5% to 18.1%, respectively, during the study period. Associations of secondhand nicotine vape exposure with bronchitic symptoms (OR 1.40, 95% CI 1.06 to 1.84) and shortness of breath (OR 1.53, 95% CI 1.06 to 2.21) were observed after controlling for vaping, active and passive exposure to tobacco or cannabis, and demographic characteristics (age, gender, race/ethnicity and parental education). Stronger associations were observed when analysis was restricted to participants who were neither smokers nor vapers. There were no associations with wheezing after adjustment for confounders. Conclusion Secondhand nicotine vape exposure was associated with increased risk of bronchitic symptoms and shortness of breath among young adults. No data are available, however, data might be requested through USC TCORS.

中文翻译：

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在家吸二手尼古丁电子烟和年轻人的呼吸道症状


理由尽管电子烟的使用率很高，但目前人们对接触二手尼古丁电子烟对健康的影响知之甚少。目的 调查暴露于二手尼古丁电子烟是否与年轻人不良呼吸道健康症状相关。方法 我们在前瞻性南加州儿童健康研究队列中调查了二手尼古丁电子烟暴露对每年报告的喘息、支气管炎症状和呼吸短促的影响。数据收集自 2014 年（平均年龄：17.3 岁）至 2019 年（平均年龄：21.9 岁）的研究参与者 (n=2097) 进行的重复年度调查。在控制相关混杂因素后，我们使用混合效应逻辑回归来评估二手尼古丁电子烟与呼吸道症状之间的关联。结果 研究期间，该人群中二手尼古丁电子烟的流行率从 11.7% 上升至 15.6%。研究期间，喘息、支气管炎症状和呼吸短促的患病率分别为 12.3% 至 14.9%、19.4% 至 26.0% 和 16.5% 至 18.1%。在控制电子烟、主动和被动接触烟草或大麻后，观察到二手尼古丁电子烟暴露与支气管症状（OR 1.40，95% CI 1.06 至 1.84）和呼吸短促（OR 1.53，95% CI 1.06 至 2.21）的关联和人口特征（年龄、性别、种族/民族和父母教育程度）。当分析仅限于既不吸烟也不吸电子烟的参与者时，观察到更强的关联。调整混杂因素后，与喘息没有关联。 结论 接触二手尼古丁电子烟与年轻人出现支气管炎症状和呼吸短促的风险增加相关。没有可用数据，但是可以通过 USC TCORS 请求数据。