The use of animals as models of human physiology is, and has been for many years, an indispensable tool for understanding the mechanisms of human disease. In Parkinson’s disease, various mouse models form the cornerstone of these investigations. Early models were developed to reflect the traditional histological features and motor symptoms of Parkinson’s disease. However, it is important that models accurately encompass important facets of the disease to allow for comprehensive mechanistic understanding and translational significance. Circadian rhythm and sleep issues are tightly correlated to Parkinson’s disease, and often arise prior to the presentation of typical motor deficits. It is essential that models used to understand Parkinson’s disease reflect these dysfunctions in circadian rhythms and sleep, both to facilitate investigations into mechanistic interplay between sleep and disease, and to assist in the development of circadian rhythm-facing therapeutic treatments. This review describes the extent to which various genetically- and neurotoxically-induced murine models of Parkinson’s reflect the sleep and circadian abnormalities of Parkinson’s disease observed in the clinic.

中文翻译：

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帕金森病和临床前模型中的睡眠和昼夜节律


使用动物作为人类生理学模型多年来一直是了解人类疾病机制不可或缺的工具。在帕金森病中，各种小鼠模型构成了这些研究的基石。早期模型的开发是为了反映帕金森病的传统组织学特征和运动症状。然而，重要的是模型准确地涵盖疾病的重要方面，以实现全面的机制理解和转化意义。昼夜节律和睡眠问题与帕金森病密切相关，并且通常在出现典型运动缺陷之前出现。用于理解帕金森病的模型必须反映昼夜节律和睡眠的这些功能障碍，这既有助于研究睡眠与疾病之间的机制相互作用，又有助于开发面向昼夜节律的治疗方法。这篇综述描述了各种遗传和神经毒性诱导的帕金森病小鼠模型在多大程度上反映了临床观察到的帕金森病的睡眠和昼夜节律异常。