To examine the mediating effect of obesity indicators on the association between daytime napping and type 2 diabetes mellitus (T2DM) qualitatively and quantitatively using baseline data from the Guangzhou Biobank Cohort Study. Twenty-nine thousand three hundred fifty-five participants aged 50+ years were included in this cross-sectional study. Mediation analysis was used to assess the mediating effect of body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) on the association between daytime napping and T2DM after adjustment for sex, age, education, occupation, smoking status, alcohol use and physical activity. The mean (standard deviation) age of participants was 61.5 ( 7.1) years. The prevalence of T2DM and daytime napping was 12.5% and 65.2%, respectively. After adjustment for potential confounders, WC, WHR and WHtR showed partial mediating effects on the association between daytime napping and T2DM, with the proportion (95% confidence interval) of mediation effect being 10.17% (8.14–14.43%), 14.91% (11.95–21.24%) and 9.36% (7.49–13.29%), respectively. No mediating effect of BMI or HC on the association between daytime napping and T2DM was found. Our results showed significant mediating effects of WC, WHR and WHtR on the association between daytime napping and T2DM, suggesting that waist circumference management could be important in daytime nappers.

中文翻译：

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肥胖指标作为白天午睡与 2 型糖尿病之间关联的中介：广州生物库队列研究

使用广州生物库队列研究的基线数据，定性和定量地检查肥胖指标对白天午睡与 2 型糖尿病 (T2DM) 之间关联的中介作用。这项横断面研究包括 29355 名 50 岁以上的参与者。采用中介分析法评估体重指数（BMI）、腰围（WC）、臀围（HC）、腰臀比（WHR）和腰高比（WHtR）对人的影响的中介作用。在对性别、年龄、教育、职业、吸烟状况、饮酒和身体活动进行调整后，白天小睡与 T2DM 之间的关联。参与者的平均（标准差）年龄为 61.5（7.1）岁。T2DM 和白天午睡的患病率分别为 12.5% 和 65.2%。调整潜在混杂因素后，WC、WHR 和 WHtR 在白天午睡与 T2DM 之间的关联中表现出部分中介效应，中介效应的比例（95% 置信区间）分别为 10.17%（8.14-14.43%）、14.91%（11.95 –21.24%) 和 9.36% (7.49–13.29%)。没有发现 BMI 或 HC 对白天午睡和 T2DM 之间的关联有中介作用。我们的结果显示 WC、WHR 和 WHtR 对白天午睡和 T2DM 之间的关联有显着的中介作用，这表明腰围管理在白天午睡中可能很重要。24%) 和 9.36% (7.49–13.29%)。没有发现 BMI 或 HC 对白天午睡和 T2DM 之间的关联有中介作用。我们的结果显示 WC、WHR 和 WHtR 对白天午睡和 T2DM 之间的关联有显着的中介作用，这表明腰围管理在白天午睡中可能很重要。24%) 和 9.36% (7.49–13.29%)。没有发现 BMI 或 HC 对白天午睡和 T2DM 之间的关联有中介作用。我们的结果显示 WC、WHR 和 WHtR 对白天午睡和 T2DM 之间的关联有显着的中介作用，这表明腰围管理在白天午睡中可能很重要。