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Novel lysosome-targeted anticancer fluorescent agents used in zebrafish and nude mouse tumour imaging
Frontiers of Chemical Science and Engineering ( IF 4.3 ) Pub Date : 2021-09-10 , DOI: 10.1007/s11705-021-2075-5 Xiuli Chen 1, 2 , Feng Liu 1 , Kun Li 1 , Yongmei Xie 1 , Zhihui Li 1, 3 , Haiying Wu 2 , Bin Chen 3 , Weihong Kuang 4
中文翻译：
用于斑马鱼和裸鼠肿瘤成像的新型溶酶体靶向抗癌荧光剂
更新日期：2021-09-10
Frontiers of Chemical Science and Engineering ( IF 4.3 ) Pub Date : 2021-09-10 , DOI: 10.1007/s11705-021-2075-5 Xiuli Chen 1, 2 , Feng Liu 1 , Kun Li 1 , Yongmei Xie 1 , Zhihui Li 1, 3 , Haiying Wu 2 , Bin Chen 3 , Weihong Kuang 4
Affiliation
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The design of three novel fatty nitrogen mustard-based anticancer agents with fluorophores incorporated into the alkene structure (CXL 118, CXL121, and CXL122) is described in this report. The results indicated that these compounds are selectively located in lysosomes and exhibit effective antitumour activity. Notably, these compounds can directly serve as both reporting and imaging agents in vitro and in vivo without the need to add other fluorescent tagging agents.
中文翻译：
用于斑马鱼和裸鼠肿瘤成像的新型溶酶体靶向抗癌荧光剂
本报告描述了三种新型脂肪氮芥类抗癌剂的设计，其中荧光团结合到烯烃结构中（CXL 118、CXL121和CXL122）。结果表明，这些化合物选择性地位于溶酶体中并表现出有效的抗肿瘤活性。值得注意的是，这些化合物可以在体外和体内直接用作报告剂和成像剂，而无需添加其他荧光标记剂。
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