Antimicrobial and anti-inflammatory activities of the neuropeptide antagonist SPA,Journal of Peptide Science

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Antimicrobial and anti-inflammatory activities of the neuropeptide antagonist SPA
Journal of Peptide Science ( IF 1.8 ) Pub Date : 2022-01-06 , DOI: 10.1002/psc.3402
Zhongwen Zhu ₁ , Yufan Yao ₁ , Sujie Huang ₁ , Ling Ma ₁ , Jingjing Song ₁ , Wei Zhang ₁

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Antimicrobial peptides have received increased attention due to the increasing prevalence of antibiotic-resistant bacteria. However, the development of antimicrobial peptides for clinical applications remains a huge challenge. SPA ([D-rg¹, D-Trp^5,7,9, Leu¹¹]SP), an analog of substance P, is a broad-spectrum neuropeptide antagonist. In this study, we found that SPA could efficiently kill Gram-positive and Gram-negative bacteria by membrane disruption, similar to antimicrobial peptides. In addition, SPA showed high killing activity toward bacteria rather than mammalian cells. Our results also demonstrated that SPA could significantly decrease the expression of proinflammatory cytokines and rescue mice from lethal septic shock induced by lipopolysaccharide (LPS). The impressive therapeutic potential of SPA, as indicated in this study, makes it a good template for developing effective antibiotics. Meanwhile, our study provides a new idea for developing multifunctional therapeutic agents to combat bacterial infections.

中文翻译：

神经肽拮抗剂 SPA 的抗菌和抗炎活性

由于抗生素耐药性细菌的流行，抗菌肽受到了越来越多的关注。然而，开发用于临床应用的抗菌肽仍然是一个巨大的挑战。SPA ([D-rg ¹ , D-Trp ^5,7,9 , Leu ¹¹]SP) 是 P 物质的类似物，是一种广谱神经肽拮抗剂。在这项研究中，我们发现 SPA 可以通过膜破坏有效地杀死革兰氏阳性和革兰氏阴性细菌，类似于抗菌肽。此外，SPA 对细菌而非哺乳动物细胞表现出高杀伤活性。我们的研究结果还表明，SPA 可以显着降低促炎细胞因子的表达，并使小鼠免受脂多糖 (LPS) 诱导的致死性感染性休克。如本研究所示，SPA 令人印象深刻的治疗潜力使其成为开发有效抗生素的良好模板。同时，我们的研究为开发抗细菌感染的多功能治疗剂提供了新思路。

更新日期：2022-01-06

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