Background

The purpose of this research is to illustrate the synthesis, characterization, and reactivity of three new mononuclear complexes (NiSniL, CuSniL, and VOSniL) from the direct coordination of sodium sulfonate pyridylhydrazone (H₂SniL) to Ni²⁺, Cu²⁺, and VO²⁺ ions, respectively. The reactivity was studied catalytically and biologically considering the type and nature of the central metal ion.

Methods

The spectral analysis of IR, NMR, and mass spectra, in addition, other essential tools (e.g., elemental and thermogravimetric analyses) were used as the main methods in the characterization of all studied compounds. All M²⁺-complexes showed high catalytic efficiency towards the 1,2-cyclooctene epoxidation with H₂O₂, in which the central metal ion presented an effective action in its complex catalyst for such catalytic processes.

The significant findings

The significant findings of the catalytic studies are summarized that VO-complex catalyst (95% after 2 h at 70 °C), with the high valence of VO²⁺ ion (V⁴⁺ ion), exhibited a little more efficiency than that of NiSniL and CuSniL (90 and 94% after 4 h at 70 °C) within low valence of Ni²⁺ and Cu²⁺ ion, respectively. The valid oxidation state (V⁴⁺/V⁵⁺) interchangeable behavior of V⁴⁺ ion, the high electrochemical reversibility, and the strong Lewis acid feature gave additional catalytic activity to VOSinL over the other studied complex catalysts. Catalytically, VOSniL catalyst could be assigned as a candidate for further industrial catalytic application, homogeneously. The effect of M²⁺ ion in their complexes was also biologically investigated. The reactivity of H₂SniL, NiSniL, CuSniL, and VOSniL towards ctDNA was investigated spectrophotometrically and evaluated with viscosity which assigned valuable interaction. The interaction of the current compounds was estimated with the binding constant (4.11, 6.01, 6.15, and 6.22 × 10⁸ mol⁻¹ dm³, respectively), which referred to their high reactivity towards ctDNA. Also, the Gibbs’ free energy values for such interaction supported their high potential against ctNDA (-32.03, -32.96, -33.02, and -33.06 kJ mol⁻¹, respectively). The investigated compounds were enhanced bioaction with ctDNA over their free ligand, which was observed with various potentials based on the M²⁺ type and displayed significant antimicrobial, antioxidant, and anticancer activities, and that were also supported within the molecular docking assessment. Therefore, from the obtained results, it could be suggested that our M-complexes with their effective antimicrobial, antioxidant, and cytotoxicity activity would be probably nominated for treatment of bacterial and fungal infections and could be also appraised clinically for further applications.

中文翻译：

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镍 (II)、铜 (II) 和氧钒 (II) 与三齿烟酰腙衍生物的配合物可用作环氧化过程的有效催化剂和生物试剂

背景

本研究的目的是说明从磺酸钠吡啶腙(H ₂ SniL)直接配位到 Ni ²⁺、Cu ²⁺、和 VO ²⁺离子，分别。考虑到中心金属离子的类型和性质，对反应性进行了催化和生物学研究。

方法

IR、NMR 和质谱的光谱分析，此外，其他基本工具（例如元素和热重分析）被用作表征所有研究化合物的主要方法。所有M ²⁺ -配合物对1,2-环辛烯与H ₂ O _{2 的}环氧化均显示出高催化效率，其中中心金属离子在其配合物催化剂中对此类催化过程表现出有效作用。

重要发现

催化研究的重要发现总结为具有高价态 VO ²⁺离子（V ⁴⁺离子）的VO 复合催化剂（70 °C 下 2 小时后为 95% ），表现出比NiSniL 和 CuSniL（70 °C 下 4 小时后分别为 90% 和 94%）在低价态的 Ni ²⁺和 Cu ²⁺离子中。有效氧化态（V ⁴⁺ / V ⁵⁺）V的可互换的行为⁴⁺离子、高电化学可逆性和强路易斯酸特征为 VOSinL 提供了比其他研究的复杂催化剂额外的催化活性。在催化方面，VOSniL 催化剂可以被指定为进一步工业催化应用的候选者。还对M ²⁺离子在其复合物中的作用进行了生物学研究。用分光光度法研究了 H ₂ SniL、NiSniL、CuSniL 和 VOSniL 对ct DNA的反应性，并用粘度评估了有价值的相互作用。当前化合物的相互作用通过结合常数（4.11、6.01、6.15 和 6.22 × 10 ⁸ mol ^-1 dm ³，分别），这指的是它们对ct DNA的高反应性。此外，这种相互作用的吉布斯自由能值支持它们对抗 ctNDA 的高潜力（分别为 -32.03、-32.96、-33.02 和 -33.06 kJ mol ^-1）。与游离配体相比，所研究的化合物与ct DNA 的生物作用增强，这在基于 M ^{2+ 的}各种电位下观察到类型并显示出显着的抗微生物、抗氧化和抗癌活性，并且在分子对接评估中也得到了支持。因此，从获得的结果可以表明，我们的 M 复合物具有有效的抗菌、抗氧化和细胞毒性活性，可能会被提名用于治疗细菌和真菌感染，也可以在临床上进行评估以进一步应用。