Background Grey matter atrophy occurs as a function of ageing and is accelerated in dementia. Previous research suggests physical activity attenuates grey matter loss; however, there appears to be individual variability in this effect. Understanding factors that can affect the relationship between physical activity and brain volume may enable prediction of individual response, and aid in identifying those that gain the greatest neural benefits from physical activity. The current study examined the relationship between objectively-measured physical activity and brain volume; and whether this relationship is moderated by age, sex, or a priori candidate genetic factors.

中文翻译：

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不可改变的因素作为身体活动和脑容量之间关系的调节因素：一项横断面英国生物银行研究

背景灰质萎缩随着衰老而发生，并在痴呆症中加速。先前的研究表明，体育活动可以减轻灰质损失；然而，这种影响似乎存在个体差异。了解可能影响体力活动与脑容量之间关系的因素可以预测个体反应，并有助于识别那些从体力活动中获得最大神经益处的因素。目前的研究检验了客观测量的体力活动与脑容量之间的关系；以及这种关系是否受到年龄、性别或先验候选遗传因素的调节。