The self-healing properties of the material synthesized based on conventional isocyanate microcapsules as a healing agent are most likely degraded by the release of CO₂ during self-healing. Herein, we report the self-healing capability in a moisture environment of a particle-encapsulated isocyanate that is activated through the curing process involving an isocyanate agent. A novel isocyanate–oxazolidine compound loaded-spherical microcapsule, with a shell thickness of 10 μm and a median diameter of 151.4 μm, is first prepared via interfacial photoinitiated thiol-ene click chemistry in a stabilized aqueous emulsion. The encapsulation of the synthesized oxazolidine enables a significant improvement in the thermal stability of the microcapsules. Furthermore, the evaluation and analysis of the self-healing properties of the polyurethane coatings based on the isocyanate–oxazolidine-loaded microcapsules provide the evidence to elucidate the self-healing pathway on the molecular level. The oxazolidine preferentially undergoes a ring-opening reaction, yielding amino and hydroxyl compounds that further react with isocyanate to achieve autonomous self-healing in a moisture environment. This study opens up a route to develop isocyanate-encapsulated self-healing materials for practical applications.

基于传统异氰酸酯微胶囊作为修复剂合成的材料的自修复性能最有可能因 CO ₂的释放而降低在自愈过程中。在此，我们报告了颗粒包封的异氰酸酯在潮湿环境中的自愈能力，该异氰酸酯通过涉及异氰酸酯试剂的固化过程被激活。首先通过界面光引发硫醇-烯点击化学在稳定的水乳液中制备了一种新型的异氰酸酯-恶唑烷化合物负载球形微胶囊，壳厚度为 10 μm，中值直径为 151.4 μm。合成的恶唑烷的包封能够显着提高微胶囊的热稳定性。此外，基于异氰酸酯-恶唑烷微胶囊的聚氨酯涂料自修复性能的评估和分析为阐明分子水平的自修复途径提供了证据。恶唑烷优先进行开环反应，产生氨基和羟基化合物，这些化合物进一步与异氰酸酯反应以在潮湿环境中实现自主自愈。该研究为开发用于实际应用的异氰酸酯包封的自修复材料开辟了一条途径。