Despite the increasing prevalence of obesity and diabetes, there is no efficient treatment to combat these epidemics. The adipose organ is the main site for energy storage and plays a pivotal role in whole body lipid metabolism and energy homeostasis, including remodeling and dysfunction of adipocytes and adipose tissues in obesity and diabetes.

Thus, restoring and balancing metabolic functions in the adipose organ is in demand. MiRNAs represent a novel class of drugs and drug targets, as they are heavily involved in the regulation of many cellular and metabolic processes and diseases, likewise in adipocytes.

In this review, we summarize key regulatory activities of miRNAs in the adipose organ, discuss various miRNA replacement and inhibition strategies, promising delivery systems for miRNAs and reflect the future of novel miRNA-based therapeutics to target adipose tissues with the ultimate goal to combat metabolic disorders.

尽管肥胖和糖尿病的患病率越来越高，但没有有效的治疗方法来对抗这些流行病。脂肪器官是能量储存的主要场所，在全身脂质代谢和能量稳态中起着举足轻重的作用，包括肥胖和糖尿病中脂肪细胞和脂肪组织的重塑和功能障碍。

因此，需要恢复和平衡脂肪器官的代谢功能。miRNA 代表了一类新的药物和药物靶点，因为它们与许多细胞和代谢过程和疾病的调节密切相关，在脂肪细胞中也是如此。

在这篇综述中，我们总结了 miRNA 在脂肪器官中的关键调节活动，讨论了各种 miRNA 替代和抑制策略，有前景的 miRNA 递送系统，并反映了靶向脂肪组织的新型 miRNA 疗法的未来，最终目标是对抗代谢障碍。