Vaccination affords protection from disease by activating pathogen-specific immune cells and facilitating the development of persistent immunologic memory toward the vaccine-specific pathogen. Current vaccine regimens are often based on the efficiency of the acute immune response, and not necessarily on the generation of memory cells, in part because the mechanisms underlying the development of efficient immune memory remain incompletely understood. This Review describes recent advances in defining memory T cell metabolism and how metabolism of these cells might be altered in patients affected by mitochondrial diseases or metabolic syndrome, who show higher susceptibility to recurrent infections and higher rates of vaccine failure. It discusses how this new understanding could add to the way we think about immunologic memory, vaccine development, and cancer immunotherapy.

中文翻译：

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靶向记忆T细胞代谢以提高免疫力


疫苗通过激活病原体特异性免疫细胞并促进针对疫苗特异性病原体的持久免疫记忆的发展来提供针对疾病的保护。目前的疫苗方案通常基于急性免疫反应的效率，而不一定基于记忆细胞的生成，部分原因是有效免疫记忆发展的机制仍未完全了解。这篇综述介绍了定义记忆 T 细胞代谢的最新进展，以及这些细胞的代谢如何在受线粒体疾病或代谢综合征影响的患者中发生改变，这些患者对反复感染的易感性更高，疫苗失败率也更高。它讨论了这种新的理解如何增加我们对免疫记忆、疫苗开发和癌症免疫治疗的思考方式。