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Enrichment of n-3 containing ether phospholipids in plasma after 30 days of krill oil compared with fish oil supplementation
Lipids ( IF 1.8 ) Pub Date : 2022-01-03 , DOI: 10.1002/lipd.12335
Hyunsin Hedy Sung 1 , Andrew J Sinclair 2 , Xiao Q Su 1
Affiliation  

There are conflicting findings over the bioavailability of long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) from krill oil (KO) compared with fish oil (FO) in short- and long-term studies. The aim of this study was to compare the effects of KO versus FO on the enrichment of molecular species of plasma phospholipids in young women following a 30-day consumption of the n-3 oils. Eleven healthy women aged 18–45 years consumed seven capsules of KO per day (containing a total of 1.27 g n-3 PUFA) or five capsules of FO per day (total of 1.44 g n-3 PUFA) for 30 days in a randomized crossover study, separated by at least a 30-day washout period. Fasting blood samples were collected at day zero (baseline), day 15 and day 30 and analyzed by HPLC-MS/MS for molecular species of phospholipids. Supplementation increased n-3 PUFA in main phospholipids classes in both groups. After 30 days of supplementation, 35 out of 70 molecular species containing eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid (DPAn-3) had a significantly greater concentration in KO group compared with the FO treated group. The majority (89%) of the differentiated molecular species were choline and ethanolamine ether-phospholipids. These data reveal that analysis of plasma phospholipids following 30 days of consumption of KO (a marine oil rich in phospholipids, including ether phospholipids) resulted in an enrichment of n-3 PUFA in molecular species of ether-phospholipids compared with FO (a triacylglycerol-rich marine oil).

中文翻译:

与补充鱼油相比,磷虾油 30 天后血浆中含 n-3 醚磷脂的富集

在短期和长期研究中,与鱼油 (FO) 相比,磷虾油 (KO) 中长链 n-3 多不饱和脂肪酸 (n-3 PUFA) 的生物利用度存在相互矛盾的发现。本研究的目的是比较 KO 与 FO 对服用 n-3 油 30 天后年轻女性血浆磷脂分子种类富集的影响。11 名年龄在 18-45 岁的健康女性每天服用 7 粒 KO 胶囊(总共含有 1.27 g n-3 PUFA)或每天服用 5 粒 FO 胶囊(总共 1.44 g n-3 PUFA),持续 30 天。交叉研究,相隔至少 30 天的清除期。在第 0 天(基线)、第 15 天和第 30 天收集空腹血样,并通过 HPLC-MS/MS 分析磷脂分子种类。补充剂增加了两组中主要磷脂类中的 n-3 PUFA。补充 30 天后,与 FO 处理组相比,含有二十碳五烯酸 (EPA)、二十二碳六烯酸 (DHA) 和二十二碳五烯酸 (DPAn-3) 的 70 种分子中的 35 种在 KO 组中具有显着更高的浓度。大多数 (89%) 的分化分子种类是胆碱和乙醇胺醚-磷脂。这些数据表明,与 FO(一种三酰基甘油-丰富的海洋石油)。与 FO 处理组相比,含有二十碳五烯酸 (EPA)、二十二碳六烯酸 (DHA) 和二十二碳五烯酸 (DPAn-3) 的 70 个分子种类中有 35 个在 KO 组中具有显着更高的浓度。大多数 (89%) 的分化分子种类是胆碱和乙醇胺醚-磷脂。这些数据表明,与 FO(一种三酰基甘油-丰富的海洋石油)。与 FO 处理组相比,含有二十碳五烯酸 (EPA)、二十二碳六烯酸 (DHA) 和二十二碳五烯酸 (DPAn-3) 的 70 个分子种类中有 35 个在 KO 组中具有显着更高的浓度。大多数 (89%) 的分化分子种类是胆碱和乙醇胺醚-磷脂。这些数据表明,与 FO(一种三酰基甘油-丰富的海洋石油)。大多数 (89%) 的分化分子种类是胆碱和乙醇胺醚-磷脂。这些数据表明,与 FO(一种三酰基甘油-丰富的海洋石油)。大多数 (89%) 的分化分子种类是胆碱和乙醇胺醚-磷脂。这些数据表明,与 FO(一种三酰基甘油-丰富的海洋石油)。
更新日期:2022-01-03
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