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Dental stem cell-derived extracellular vesicles as promising therapeutic agents in the treatment of diseases
International Journal of Oral Science ( IF 10.8 ) Pub Date : 2022-01-04 , DOI: 10.1038/s41368-021-00152-2
Ye Li 1 , Xu Duan 1 , Yinxue Chen 1 , Bingyun Liu 1 , Gang Chen 1, 2, 3
Affiliation  

Dental stem cells (DSCs), an important source of mesenchymal stem cells (MSCs), can be easily obtained by minimally invasive procedures and have been used for the treatment of various diseases. Classic paradigm attributed the mechanism of their therapeutic action to direct cell differentiation after targeted migration, while contemporary insights into indirect paracrine effect opened new avenues for the mystery of their actual low engraftment and differentiation ability in vivo. As critical paracrine effectors, DSC-derived extracellular vesicles (DSC-EVs) are being increasingly linked to the positive effects of DSCs by an evolving body of in vivo studies. Carrying bioactive contents and presenting therapeutic potential in certain diseases, DSC-EVs have been introduced as promising treatments. Here, we systematically review the latest in vivo evidence that supports the therapeutic effects of DSC-EVs with mechanistic studies. In addition, current challenges and future directions for the clinical translation of DSC-EVs are also highlighted to call for more attentions to the (I) distinguishing features of DSC-EVs compared with other types of MSC-EVs, (II) heterogeneity among different subtypes of DSC-derived EVs, (III) action modes of DSC-EVs, (IV) standardization for eligible DSC-EVs and (V) safety guarantee for the clinical application of DSC-EVs. The present review would provide valuable insights into the emerging opportunities of DSC-EVs in future clinical applications.



中文翻译:

牙科干细胞衍生的细胞外囊泡作为治疗疾病的有希望的治疗剂

牙科干细胞 (DSCs) 是间充质干细胞 (MSCs) 的重要来源,可以通过微创手术轻松获得,并已用于治疗各种疾病。经典范式将它们的治疗作用机制归因于靶向迁移后的直接细胞分化,而当代对间接旁分泌效应的见解为它们在体内的实际低植入和分化能力之谜开辟了新途径。作为关键的旁分泌效应器,DSC 衍生的细胞外囊泡 (DSC-EV) 通过不断发展的体内研究越来越多地与 DSC 的积极作用相关联。DSC-EV 具有生物活性成分并在某些疾病中具有治疗潜力,已被引入作为有前景的治疗方法。这里,我们系统地回顾了最新的体内证据,这些证据支持 DSC-EVs 的治疗效果和机理研究。此外,还强调了 DSC-EVs 临床转化的当前挑战和未来方向,以呼吁更多关注 (I) DSC-EVs 与其他类型的 MSC-EVs 相比的区别特征,(II) 不同类型之间的异质性DSC-EVs 的亚型,(III) DSC-EVs 的作用模式,(IV) 符合条件的 DSC-EVs 的标准化和 (V) DSC-EVs 临床应用的安全保证。本综述将为 DSC-EV 在未来临床应用中的新兴机会提供有价值的见解。还强调了 DSC-EV 临床转化的当前挑战和未来方向,以呼吁更多关注 (I) DSC-EV 与其他类型的 MSC-EV 相比的显着特征,(II) DSC 不同亚型之间的异质性衍生电动汽车,(三)DSC-EV的作用模式,(IV)合格DSC-EV的标准化和(V)DSC-EV临床应用的安全保证。本综述将为 DSC-EV 在未来临床应用中的新兴机会提供有价值的见解。还强调了 DSC-EV 临床转化的当前挑战和未来方向,以呼吁更多关注 (I) DSC-EV 与其他类型的 MSC-EV 相比的显着特征,(II) DSC 不同亚型之间的异质性衍生电动汽车,(三)DSC-EV的作用模式,(IV)合格DSC-EV的标准化和(V)DSC-EV临床应用的安全保证。本综述将为 DSC-EV 在未来临床应用中的新兴机会提供有价值的见解。(IV) 符合条件的 DSC-EV 的标准化和 (V) DSC-EV 临床应用的安全保障。本综述将为 DSC-EV 在未来临床应用中的新兴机会提供有价值的见解。(IV) 符合条件的 DSC-EV 的标准化和 (V) DSC-EV 临床应用的安全保障。本综述将为 DSC-EV 在未来临床应用中的新兴机会提供有价值的见解。

更新日期:2022-01-04
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