Objective: Ongoing studies are focused on adapting transcranial magnetic stimulation (TMS) for the treatment of major depressive disorder in adolescent humans. Most protocols in adolescent humans to date have delivered daily 10 Hz prefrontal stimulation with mixed results. Novel TMS dosing strategies such as accelerated TMS have recently been considered. There are knowledge gaps related to the potential clinical and pragmatic advantages of accelerated TMS. This pilot study compared the behavioral effects of a standard daily and accelerated low-intensity TMS (LI-TMS) protocol in an adolescent murine model of depression.

中文翻译：

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标准与加速经颅磁刺激治疗青少年抑郁症的临床前研究

目的：正在进行的研究主要集中在采用经颅磁刺激 (TMS) 治疗青少年重度抑郁症。迄今为止，针对青少年人类的大多数协议每天都会提供 10 Hz 的前额叶刺激，但结果不一。最近考虑了新的 TMS 给药策略，例如加速 TMS。与加速 TMS 的潜在临床和实用优势相关的知识差距。这项初步研究比较了标准每日和加速低强度 TMS (LI-TMS) 方案对青春期抑郁症小鼠模型的行为影响。