A protocol for a retrospective observational study to investigate the effect of frailty on outcomes of older adults admitted with major trauma. Patient data will be examined held within the Trauma and Audit Research Network (TARN) database, from 23 Major Trauma Centres in England, between April 2019 and March 2020. The two research questions are: 1) Is there any association between frailty and clinical outcomes in older people admitted with serious traumatic injuries? 2) Is there any association between a geriatrician review and clinical outcomes in an older people admitted with serious traumatic injuries? Patients 65 years old or over will be included. The primary outcome will be mortality as measured by time from hospital admission to death. Secondary outcomes will include day 30 mortality, post injury complications, and length of hospital stay. A mixed-effects multivariable Cox proportional hazards model will be used to analyse the data. A statistical analysis plan has been produced separately for each research question.

中文翻译：

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一项回顾性观察研究，调查虚弱对因重大创伤入院的老年人结局的影响

一项回顾性观察研究的协议，旨在调查虚弱对因重大创伤入院的老年人的结果的影响。2019 年 4 月至 2020 年 3 月期间，将检查来自英格兰 23 个主要创伤中心的创伤和审计研究网络 (TARN) 数据库中保存的患者数据。两个研究问题是：1) 虚弱与临床结果之间是否存在关联在因严重外伤入院的老年人中？2) 对于因严重外伤入院的老年人，老年科医生的复查与临床结果之间是否存在关联？将包括 65 岁或 65 岁以上的患者。主要结果将是死亡率，以从入院到死亡的时间衡量。次要结果将包括第 30 天死亡率、受伤后并发症和住院时间。将使用混合效应多变量 Cox 比例风险模型来分析数据。针对每个研究问题分别制定了统计分析计划。