Abstract

Background: Hepatoblastoma (HB) is malignant embryonal tumor typically arising in infants and young children. Yes-associated protein (YAP) is aberrantly activated in various tumors; however, the role of YAP in hepatoblastoma is still unexplored. Methods: We assessed YAP expression in hepatoblastoma using immunohistochemistry. The relationships to clinicopathology and survival were analyzed. Results: Positive rate of YAP expression was higher in hepatoblastoma than in adjacent tissues. YAP overexpression was significantly correlated with lymph node metastasis and vascular invasion. Both epithelial and mixed histological types expressed YAP, but high expression was more frequent in MT. YAP expression correlated with VEGF expression, high microvascular density and low overall survival. Multivariable Cox regression analysis revealed that YAP was an independent prognostic factor for survival in children with hepatoblastoma. Conclusion: In hepatoblastoma, YAP may promote VEGF induced angiogenesis and metastases, with resulting poorer prognosis, representing a potential adverse prognostic marker.

摘要

背景：肝母细胞瘤（HB）是典型的发生于婴幼儿的恶性胚胎肿瘤。Yes 相关蛋白 (YAP) 在各种肿瘤中异常激活；然而，YAP 在肝母细胞瘤中的作用仍有待探索。方法：我们使用免疫组织化学评估了肝母细胞瘤中 YAP 的表达。分析与临床病理学和生存的关系。结果：肝母细胞瘤中 YAP 表达的阳性率高于邻近组织。YAP过表达与淋巴结转移和血管侵犯显着相关。上皮和混合组织学类型均表达 YAP，但高表达在 MT 中更常见。YAP 表达与 VEGF 表达、高微血管密度和低总生存率相关。多变量 Cox 回归分析显示，YAP 是肝母细胞瘤患儿生存的独立预后因素。结论：在肝母细胞瘤中，YAP可能促进VEGF诱导的血管生成和转移，导致预后较差，是潜在的不良预后标志物。