The repair of bone defects, especially for the large segment of bone defects, has always been an urgent problem in orthopedic clinic and attracted researchers' attention. Nowadays, the application of tissue engineering bone in the repair of bone defects has become the research hotspot. With the rapid development of tissue engineering, the novel and functional scaffold materials for bone repair have emerged. In this review, we have summarized the multi-functional roles of osteoclasts in bone remodeling. The development of matrix-based tissue engineering bone has laid a theoretical foundation for further investigation about the novel bone regeneration materials which could perform high bioactivity. From the point of view on preserving pre-osteoclasts and targeting mature osteoclasts, this review introduced the novel matrix-based tissue engineering bone based on osteoclasts in the field of bone tissue engineering, which provides a potential direction for the development of novel scaffold materials for the treatment of bone defects.

中文翻译：

---

基于基质的组织工程骨中的多功能破骨细胞。

骨缺损的修复，尤其是大段骨缺损的修复，一直是骨科临床亟待解决的问题，备受研究者关注。目前，组织工程骨在骨缺损修复中的应用已成为研究热点。随着组织工程的快速发展，新型功能性骨修复支架材料应运而生。在这篇综述中，我们总结了破骨细胞在骨重塑中的多功能作用。基质基组织工程骨的发展为进一步研究具有高生物活性的新型骨再生材料奠定了理论基础。从保存前破骨细胞和靶向成熟破骨细胞的角度来看，