A widespread application of three-dimensional (3D) bioprinting in basic and translational research requires the accessibility to affordable printers able to produce physiologically relevant tissue models. To facilitate the use of bioprinting as a standard technique in biology, an open-source device based on a consumer-grade 3D stereolithographic (SL) printer was developed. This SL bioprinter can produce complex constructs that preserve cell viability and recapitulate the physiology of tissues. The detailed documentation of the modifications apported to the printer as well as a throughout performance analysis allow for a straightforward adoption of the device in other labs and its customization for specific applications. Given the low cost, several modified bioprinters could be simultaneously operated for a highly parallelized tissue production.

中文翻译：

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使用升级的消费者立体光刻 3D 打印机生物打印肿瘤微环境

三维 (3D) 生物打印在基础和转化研究中的广泛应用需要能够获得能够产生生理相关组织模型的负担得起的打印机。为了促进生物打印作为生物学标准技术的使用，开发了一种基于消费级 3D 立体光刻 (SL) 打印机的开源设备。这种 SL 生物打印机可以产生复杂的结构，以保持细胞活力并概括组织的生理学。分配给打印机的修改的详细文档以及全面的性能分析允许在其他实验室直接采用该设备并针对特定应用进行定制。鉴于成本低，可以同时操作几个改进的生物打印机以实现高度并行的组织生产。