A diphenyl prolinol TMS ether-catalyzed stereoselective reaction of 1-bromo-2-naphthols with enals has been developed. The organocatalyzed cross coupling-like reaction servers an efficient approach to sterically congested (E)-α-naphthyl enals. The formal C(sp2)-C(sp2) cross-coupling products are obtained in good yields and with excellent stereoselectivities in favor of E-isomers. A broad range of aromatic enals and 1-bromo-2-naphthols are tolerated. The synthetic strategy significantly expands the scope of the organocatalytic cross-coupling-like reactions by enabling sterically demanding 1-bromo-2-naphthols as viable substrates.

中文翻译：

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1-溴-2-萘酚与烯醛类交叉偶联反应的氨基催化立体选择性合成 (E)-α-萘烯醛

开发了二苯基脯氨醇 TMS 醚催化的 1-溴-2-萘酚与烯醛的立体选择性反应。有机催化的类交叉偶联反应为空间拥挤的 (E)-α-萘烯提供了一种有效的方法。正式的 C(sp2)-C(sp2) 交叉偶联产物以良好的收率获得，并且具有极好的立体选择性，有利于 E 异构体。可耐受范围广泛的芳香烯醛和 1-溴-2-萘酚。该合成策略通过使空间要求高的 1-溴-2-萘酚作为可行的底物，显着扩大了有机催化交叉偶联反应的范围。