Endocrine disorders in survivors of childhood, adolescent, and young adult (CAYA) cancers are associated with substantial adverse physical and psychosocial effects. To improve appropriate and timely endocrine screening and referral to a specialist, the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) aims to develop evidence and expert consensus-based guidelines for healthcare providers that harmonize recommendations for surveillance of endocrine disorders in CAYA cancer survivors. Existing IGHG surveillance recommendations for premature ovarian insufficiency, gonadotoxicity in males, fertility preservation, and thyroid cancer are summarized. For hypothalamic-pituitary (HP) dysfunction, new surveillance recommendations were formulated by a guideline panel consisting of 42 interdisciplinary international experts. A systematic literature search was performed in MEDLINE (through PubMed) for clinically relevant questions concerning HP dysfunction. Literature was screened for eligibility. Recommendations were formulated by drawing conclusions from quality assessment of all evidence, considering the potential benefits of early detection and appropriate management. Healthcare providers should be aware that CAYA cancer survivors have an increased risk for endocrine disorders, including HP dysfunction. Regular surveillance with clinical history, anthropomorphic measures, physical examination, and laboratory measurements is recommended in at-risk survivors. When endocrine disorders are suspected, healthcare providers should proceed with timely referrals to specialized services. These international evidence-based recommendations for surveillance of endocrine disorders in CAYA cancer survivors inform healthcare providers and highlight the need for long-term endocrine follow-up care in subgroups of survivors and elucidate opportunities for further research.

中文翻译：

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儿童癌症幸存者的下丘脑-垂体和其他内分泌监测。

儿童、青少年和青年 (CAYA) 癌症幸存者的内分泌失调与严重的不良生理和社会心理影响有关。为了改进适当和及时的内分泌筛查和转诊给专家，国际儿童癌症晚期影响指南协调小组 (IGHG) 旨在为医疗保健提供者制定基于证据和专家共识的指南，以协调 CAYA 癌症内分泌疾病监测的建议幸存者。总结了针对卵巢早衰、男性性腺毒性、保留生育能力和甲状腺癌的现有 IGHG 监测建议。对于下丘脑-垂体 (HP) 功能障碍，由 42 位跨学科国际专家组成的指南小组制定了新的监测建议。在 MEDLINE（通过 PubMed）中对有关 HP 功能障碍的临床相关问题进行了系统的文献检索。对文献进行了资格筛选。考虑到早期发现和适当管理的潜在益处，通过对所有证据的质量评估得出结论来制定建议。医疗保健提供者应该意识到 CAYA 癌症幸存者患内分泌疾病的风险增加，包括 HP 功能障碍。建议对有风险的幸存者进行定期监测，包括临床病史、拟人化测量、体格检查和实验室测量。当怀疑内分泌紊乱时，医疗保健提供者应及时转诊至专业服务机构。