Background and Context: Realization of the life-saving potential of “take-home naloxone” has been a personal journey, but it has also been a collective journey. It has been a story of individual exploration and growth, and also a story of changes at a societal level. “Take-home naloxone” has matured since its first conceptualization a quarter of a century ago. It required recognition of the enormous burden of deaths from drug overdose (particularly heroin and other opioids), and also realization of critical clusterings (such as post-release from prison). It also required realization that, since many overdose deaths are witnessed, we can potentially prevent many deaths by mobilizing drug users themselves, their families, and the wider caring community to act as intervention workforce to give life-saving interim emergency care. Summary of Scope: This article explores 5 areas (many illustrations UK-based where the author works): firstly, the need for strong science; secondly, our improved understanding of opioid overdose and deaths; thirdly, the search for greater impact from our policies and interventions; fourthly, developing better forms of naloxone; and fifthly, examining the challenges still to be addressed. Key Messages: “Take-home naloxone” is an exemplar of harm reduction with potential global impact – drug policy and practice for the public good. However, “having the potential” is not good enough – there needs to be actual implementation. This will be easier once the component parts of “take-home naloxone” are improved (better naloxone products, better training aids, revised legislation, and explicit funding support). Many improvements are already possible, but we hesitate about implementation. It is our responsibility to drive progress faster. With “take-home naloxone,” we can be proud of what we have achieved, but we must also be humble about how much more we still need to do.
Eur Addict Res

中文翻译：

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带回家的纳洛酮和预防海洛因过量死亡：追求强大的科学，更全面的理解，更大的影响

背景和背景：实现“带回家的纳洛酮”拯救生命的潜力是个人的旅程，但也是集体的旅程。这是一个个人探索和成长的故事，也是一个社会层面变化的故事。“带回家的纳洛酮”自 25 年前首次概念化以来已经成熟。它需要认识到药物过量（特别是海洛因和其他阿片类药物）造成的巨大死亡负担，还需要认识到关键的集群（例如出狱后）。它还需要认识到，由于目睹了许多过量死亡，我们可以通过动员吸毒者自己、他们的家人和更广泛的关怀社区充当干预人员提供挽救生命的临时紧急护理，从而潜在地预防许多死亡。范围总结：本文探讨了 5 个领域（许多插图来自作者工作的英国）：首先，需要强大的科学；其次，我们提高了对阿片类药物过量和死亡的理解；第三，寻求我们的政策和干预措施产生更大的影响；第四，开发更好的纳洛酮形式；第五，审查仍有待解决的挑战。关键信息：“带回家的纳洛酮”是具有潜在全球影响的减少危害的典范——为公共利益而制定的药物政策和实践。然而，“有潜力”还不够——需要有实际的实施。一旦“带回家的纳洛酮”的组成部分得到改进（更好的纳洛酮产品、更好的培训辅助、修订的立法和明确的资金支持），这将更容易。许多改进已经成为可能，但我们对实施犹豫不决。加快进步是我们的责任。有了“带回家的纳洛酮”，我们可以为我们所取得的成就感到自豪，但我们也必须对我们还需要做的事情保持谦虚。
欧洲瘾君子水库