Background: Allergic asthma was considered as an inflammation mediated by specific CD4⁺ helper lymphocytes (Th2); however, this paradigm changed in 2005, when a third group of helper cells called Th17 cells were identified. Th17 lymphocytes are the main source of interleukin (IL)-17A–F, IL-21, and IL-22; however, their physiological role in children is unclear. This study aimed to determine the percentage of Th17 cells and IL-17A in pediatric patients diagnosed with asthma and to associate it with disease control using a validated questionnaire.

中文翻译：

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哮喘儿童的 Th17 淋巴细胞：它们会影响控制吗？

背景：过敏性哮喘被认为是由特异性 CD4 ⁺辅助淋巴细胞 (Th2) 介导的炎症；然而，这种模式在 2005 年发生了变化，当时发现了第三组称为 Th17 细胞的辅助细胞。Th17 淋巴细胞是白介素 (IL)-17A–F、IL-21 和 IL-22 的主要来源；然而，它们在儿童中的生理作用尚不清楚。本研究旨在确定诊断为哮喘的儿科患者中 Th17 细胞和 IL-17A 的百分比，并使用经过验证的问卷将其与疾病控制相关联。