Objective

Osteoarthritis (OA) started to be associated to shifted microbiota composition recently. This systematic review aims to elucidate if there is a common microbiota composition linked with OA between different studies.

Methods

We screened PubMed, Scopus, Web of Science and Cochrane databases up to July 26^th 2021 to identify original studies in which microbiome was assessed from OA individuals, both in human and laboratory animals’ studies. Bacteria associated with OA were summarized to find common patterns between the studies.

Results

We identified 37 original studies where the microbiota composition was assessed in OA subjects. We identified some bacteria (Clostridium, Streptococcus, Bacteroides and Firmicutes) that were reported to be upregulated in OA subjects, whereas Lactobacillus and Bifidobacterium longum were associated with improved OA outcomes. The heterogeneity of sampling and analysis methods, different taxonomical levels reported and the lack of healthy controls in several studies made it difficult to compare the studies and reach conclusions about a potential causal link.

Conclusions

The current study demonstrated that some bacteria were identified as regulators of OA. Future works following standardized methodologies with more proper controls are needed to elucidate our understanding of the role of the microbiota in OA pathogenesis and progress towards new treatments.

中文翻译：

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骨关节炎受试者微生物组组成的系统评价

客观的

最近，骨关节炎 (OA) 开始与改变的微生物群组成有关。本系统评价旨在阐明不同研究之间是否存在与 OA 相关的共同微生物群组成。

方法

^{我们筛选了截至 2021 年 7 月 26日}的 PubMed、Scopus、Web of Science 和 Cochrane 数据库，以确定在人类和实验动物研究中对 OA 个体的微生物组进行评估的原始研究。总结了与 OA 相关的细菌，以找到研究之间的共同模式。

结果

我们确定了 37 项原始研究，其中评估了 OA 受试者的微生物群组成。我们确定了一些细菌（梭菌属、链球菌属、拟杆菌属和厚壁菌门），据报道这些细菌在 OA 受试者中上调，而乳酸杆菌和长双歧杆菌与改善的 OA 结果相关。抽样和分析方法的异质性、报告的不同分类水平以及几项研究中缺乏健康对照使得难以比较这些研究并就潜在的因果关系得出结论。

结论

目前的研究表明，一些细菌被确定为 OA 的调节剂。未来的工作需要遵循具有更适当控制的标准化方法，以阐明我们对微生物群在 OA 发病机制中的作用的理解以及新疗法的进展。