The study aims to explore the relationship between plasma insulin secretion and arterial stiffness in nondiabetic essential hypertensive patients. A total of 730 nondiabetic essential hypertensive patients registered between January 2016 and October 2020 were enrolled. A two-hour oral glucose tolerance test (OGTT) was performed to detect the levels of C-peptide and blood glucose at 0 hours and 2 hours, as well as the difference between C-peptide (Δ C-peptide) and blood glucose (Δ blood glucose) over the same period. Patients were divided into two groups: the normal glucose tolerance (NGT) group (n = 322) and the impaired glucose tolerance (IGT) group (n = 408). A multiple linear regression analysis was used to evaluate the association between brachial-ankle pulse wave velocity (baPWV) and the other factors. 0 h C-peptide, 2 h C-peptide, and Δ C-peptide were found to be higher in the IGT group. baPWV was positively linear correlated with 2 h C-peptide (r = 0.086, ) and Δ C-peptide (r = 0.115, ). baPWV remained independently associated with 0 h C-peptide, 2 h C-peptide, and Δ C-peptide, after adjusting by age, gender, smoking, body mass index (BMI), high-density lipoprotein (HDL), cholesterol, systolic blood pressure (SBP), and triglycerides (TG). Our data shows that higher endogenous insulin secretion might play an important role in the progression of arterial stiffness in nondiabetic essential hypertensive patients.

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原发性高血压患者胰岛素分泌与动脉僵硬度的关系

该研究旨在探讨非糖尿病原发性高血压患者血浆胰岛素分泌与动脉僵硬度之间的关系。共纳入 2016 年 1 月至 2020 年 10 月期间登记的 730 名非糖尿病原发性高血压患者。进行两小时口服葡萄糖耐量试验（OGTT），检测0小时和2小时C肽和血糖水平，以及C肽（ΔC肽）和血糖的差异（ Δ血糖）在同一时期。患者分为两组：糖耐量正常（NGT）组（n  =322）和糖耐量异常（IGT）组（n = 408）。多元线性回归分析用于评估臂踝脉搏波速度 (baPWV) 与其他因素之间的关联。发现 0 h C-肽、2 h C-肽和 Δ C-肽在 IGT 组中更高。baPWV 与 2 h C 肽呈正线性相关 ( r  = 0.086,)和 ΔC-肽 ( r  = 0.115,）。在按年龄、性别、吸烟、体重指数 (BMI)、高密度脂蛋白 (HDL)、胆固醇、收缩压进行调整后，baPWV 仍然与 0 h C-肽、2 h C-肽和ΔC-肽独立相关血压 (SBP) 和甘油三酯 (TG)。我们的数据显示，较高的内源性胰岛素分泌可能在非糖尿病原发性高血压患者的动脉僵硬度进展中起重要作用。