Nanotechnology industry focuses primarily on promoting nanoscience as a “green” technology to provide a way for less-toxic environmentally benign economic expansion and to synthesize eco- friendly and innocuous drugs to cater to the needs of the contemporary world. An attempt has been made to prepare silver, gold and copper nanoparticles using the aqueous flower extract of Azhadiracta indica (neem). In-vitro anti-oxidant efficacy of these metal nanoparticles (NPs) were investigated through i) Hydrogen atom transfer (HAT) reaction based assays- (ABTS scavenging effect and Hydroxyl radical scavenging effect) and ii) Electron transfer (ET) reaction based assays(DPPH radical scavenging activity and NO free radical scavenging activity). CuNPs exhibits better activity compared to AgNPs and AuNPs. In vitro anti-diabetic test was conducted for all the three NPs through three methods namely inhibition of α- glucosidase enzyme assay, inhibition of alpha amylase enzyme assay and Non-enzymatic glycosylation of hemoglobin assay. CuNPs had a remarkable anti-diabetic activity which was close to the standard acarbose.

中文翻译：

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使用 Azhadirachta indica 花合成的银、金和铜纳米粒子的体外抗氧化和体外抗糖尿病研究。

纳米技术产业主要侧重于将纳米科学作为一种“绿色”技术进行推广，为毒性较小的环境良性经济扩张提供途径，并合成生态友好、无毒的药物以满足当代世界的需求。已经尝试使用印度楝树（neem）的水花提取物制备银、金和铜纳米颗粒。这些金属纳米粒子 (NP) 的体外抗氧化功效通过 i) 基于氢原子转移 (HAT) 反应的测定-（ABTS 清除作用和羟基自由基清除作用）和 ii) 基于电子转移 (ET) 反应的测定进行研究(DPPH自由基清除活性和NO自由基清除活性)。与 AgNPs 和 AuNPs 相比，CuNPs 表现出更好的活性。通过三种方法即抑制α-葡萄糖苷酶测定法、抑制α-淀粉酶测定法和血红蛋白非酶促糖基化测定法对所有三种NP进行体外抗糖尿病试验。CuNPs 具有显着的抗糖尿病活性，接近标准的阿卡波糖。