Cervical cancer (CC) is one of the most threatening diseases in women. Circular RNAs (circRNAs) have been reported to be cancer hallmarks, but typical circRNAs in CC were rarely indicated. Through high-throughput sequencing in CC and normal cervix tissues, circYPEL2 (hsa_circ_0005600) was proposed as a candidate circRNA. CircYPEL2 exhibited significantly high expression in CC tissue and strong stability in CC cell lines. Furthermore, knockdown and overexpression of circYPEL2 indicated the potential involvement in CC proliferation, migration and invasion. Finally, the downstream regulatory genes of circYPEL2 were investigated by knockdown experiment in CC cell lines with high-throughput sequencing. In summary, our work identified circYPEL2 as a potential biomarker for clinical research of cervical cancer.

中文翻译：

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环状 RNA circYPEL2：一种新型宫颈癌生物标志物

宫颈癌（CC）是女性中最危险的疾病之一。据报道，环状 RNA (circRNA) 是癌症标志物，但 CC 中的典型 circRNA 很少被指出。通过对 CC 和正常宫颈组织进行高通量测序，提出了 circYPEL2 (hsa_circ_0005600) 作为候选 circRNA。CircYPEL2 在 CC 组织中表现出显着的高表达，在 CC 细胞系中表现出很强的稳定性。此外，circYPEL2 的敲低和过表达表明可能参与 CC 增殖、迁移和侵袭。最后，通过高通量测序CC细胞系的敲低实验研究了circYPEL2的下游调控基因。总之，我们的工作将 circYPEL2 确定为宫颈癌临床研究的潜在生物标志物。