Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance,Hepatology

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Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance
Hepatology ( IF 12.9 ) Pub Date : 2021-12-20 , DOI: 10.1002/hep.32289
Jelena Remetic ₁ , Ahmed Ghallab _{2,

3} , Zaynab Hobloss ₂ , Lisa Brackhagen ₂ , Reham Hassan _{2,

3} , Maiju Myllys ₂ , Richard Radun ₁ , Veronika Mlitz ₁ , Ci Zhu ₁ , Maximilian Baumgartner ₄ , Waltraud C Schrottmaier ₅ , Marion Mussbacher ₆ , Gerald Timelthaler ₇ , Hubert Scharnagl ₈ , Tatjana Stojakovic ₉ , Alice Assinger ₅ , Claudia D Fuchs ₁ , Jan G Hengstler ₂ , Michael Trauner ₁

Affiliation

Hans Popper Laboratory of Molecular HepatologyDivision of Gastroenterology and HepatologyDepartment of Internal Medicine IIIMedical University of ViennaViennaAustria.
Leibniz Research Centre for Working Environment and Human Factors (IfADo)DortmundGermany.
Department of Forensic Medicine and ToxicologyFaculty of Veterinary MedicineSouth Valley UniversityQenaEgypt.
Division of Gastroenterology and HepatologyDepartment of Internal Medicine IIIMedical University of ViennaViennaAustria.
Institute of Vascular Biology and Thrombosis ResearchCentre of Physiology and PharmacologyMedical University of ViennaViennaAustria.
Institute of Pharmaceutical SciencesDepartment of Pharmacology and ToxicologyUniversity of GrazGrazAustria.
The Institute of Cancer ResearchDepartment of Medicine IMedical University of ViennaViennaAustria.
Clinical Institute of Medical and Chemical Laboratory DiagnosticsMedical University of GrazGrazAustria.
Clinical Institute of Medical and Chemical Laboratory DiagnosticsUniversity Hospital GrazGrazAustria.

Lipopolysaccharide (LPS) clearance is delayed in cholestatic liver diseases. While compromised clearance by Kupffer cells (KCs) is involved, the role of LPS uptake into hepatocytes and canalicular excretion remains unclear.

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