Skin aging is the progressive biological process generally characterized by the appearance of wrinkles, age spots, sagging of skin, and dryness. Since skin is an essential part of physical appearance, this has led to increased concerns about skincare. Anti-aging products help in improving the quality and health of the skin by nourishing it. However, due to large particle size they are less efficacious. Nanotechnological approaches for topical anti-aging products have a significant effect on the product performance. Lipidic, polymeric, and metallic nanoparticles have shown potential advantages like enhanced stability and efficacy due to their smaller size. The excipients used in these nanoformulations play an important role in improving the efficacy and shelf-life of the product. The optimal selection of excipients plays a major role in the nanoformulation approach for their enhanced efficacy and stability. For the past three decades the ingredients of natural origin for cosmetic formulations have been widely recognized for being safe and less toxic. The objective of this article is to review the nanoformulations used in anti-aging along with the potential excipients used, currently marketed formulations, and patents filed for cosmetic use. Recent updates related to regulatory aspects of the nanocosmetics have also been highlighted.

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抗衰老纳米制剂综述：纳米药妆辅料和监管指南的最新进展

皮肤老化是一个渐进的生物过程，通常以皱纹、老年斑、皮肤下垂和干燥为特征。由于皮肤是外观的重要组成部分，这导致人们对护肤品的担忧增加。抗衰老产品通过滋养皮肤来帮助改善皮肤的质量和健康。然而，由于粒径大，它们的效果较差。局部抗衰老产品的纳米技术方法对产品性能有显着影响。脂质、聚合物和金属纳米粒子由于其较小的尺寸而显示出潜在的优势，例如增强的稳定性和功效。这些纳米制剂中使用的赋形剂在提高产品的功效和保质期方面发挥着重要作用。赋形剂的最佳选择在纳米制剂方法中起着重要作用，因为它们增强了功效和稳定性。在过去的三十年里，用于化妆品配方的天然成分已被广泛认为是安全且毒性较低的。本文的目的是回顾用于抗衰老的纳米制剂以及使用的潜在赋形剂、目前销售的制剂和化妆品用途专利。还强调了与纳米化妆品监管方面相关的最新更新。本文的目的是回顾用于抗衰老的纳米制剂以及使用的潜在赋形剂、目前销售的制剂和化妆品用途专利。还强调了与纳米化妆品监管方面相关的最新更新。本文的目的是回顾用于抗衰老的纳米制剂以及使用的潜在赋形剂、目前销售的制剂和化妆品用途专利。还强调了与纳米化妆品监管方面相关的最新更新。