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Estrogen Receptor β-Targeted Near-Infrared Inherently Fluorescent Probe: A Potent Tool for Estrogen Receptor β Research
ACS Sensors ( IF 8.2 ) Pub Date : 2021-12-16 , DOI: 10.1021/acssensors.1c01771 Qiuyu Meng 1 , Baohua Xie 1 , Huiguang Yu 1 , Kang Shen 1 , Xiangping Deng 1 , Hai-Bing Zhou 1, 2 , Chune Dong 1
ACS Sensors ( IF 8.2 ) Pub Date : 2021-12-16 , DOI: 10.1021/acssensors.1c01771 Qiuyu Meng 1 , Baohua Xie 1 , Huiguang Yu 1 , Kang Shen 1 , Xiangping Deng 1 , Hai-Bing Zhou 1, 2 , Chune Dong 1
Affiliation
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Estrogen receptor β (ERβ) is associated with many diseases, and ERβ probes can help to reveal the complex role of ERβ and promote the development of ERβ-targeted therapy. Herein, we designed and synthesized the first ERβ-targeted near-infrared (NIR) inherently fluorescent probe P5, which showed the advantages of high ERβ selectivity, good optical properties, and excellent ERβ imaging capability in living cells. The probe was successfully utilized to explore ERβ motion characteristic, and for the first time, the diffusion coefficient of ERβ was obtained. Moreover, P5 was also successfully applied to the in vivo imaging of ERβ in the prostate cancer mice model. Therefore, this ERβ-targeted NIR probe might be employed as a potential tool for the research of ERβ and related diseases.
中文翻译：
雌激素受体β靶向近红外固有荧光探针：雌激素受体β研究的有力工具
雌激素受体β（ERβ）与多种疾病相关，ERβ探针有助于揭示ERβ的复杂作用，促进ERβ靶向治疗的发展。在此，我们设计并合成了第一个以ERβ为靶点的近红外（NIR）固有荧光探针P5，该探针具有ERβ选择性高、光学性能好、在活细胞中ERβ成像能力优异等优点。利用该探针成功探索了ERβ的运动特性，并首次获得了ERβ的扩散系数。此外，P5也成功应用于体内ERβ在前列腺癌小鼠模型中的成像。因此，这种靶向 ERβ 的 NIR 探针可能被用作研究 ERβ 和相关疾病的潜在工具。
更新日期：2022-01-28
中文翻译：
雌激素受体β靶向近红外固有荧光探针：雌激素受体β研究的有力工具
雌激素受体β（ERβ）与多种疾病相关，ERβ探针有助于揭示ERβ的复杂作用，促进ERβ靶向治疗的发展。在此，我们设计并合成了第一个以ERβ为靶点的近红外（NIR）固有荧光探针P5，该探针具有ERβ选择性高、光学性能好、在活细胞中ERβ成像能力优异等优点。利用该探针成功探索了ERβ的运动特性，并首次获得了ERβ的扩散系数。此外，P5也成功应用于体内ERβ在前列腺癌小鼠模型中的成像。因此，这种靶向 ERβ 的 NIR 探针可能被用作研究 ERβ 和相关疾病的潜在工具。
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