A prospective study of direct-acting antiviral effectiveness and relapse risk in HCV cryoglobulinemic vasculitis by the Italian PITER cohort,Hepatology

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A prospective study of direct-acting antiviral effectiveness and relapse risk in HCV cryoglobulinemic vasculitis by the Italian PITER cohort
Hepatology ( IF 12.9 ) Pub Date : 2021-12-16 , DOI: 10.1002/hep.32281
Loreta A Kondili ₁ , Monica Monti ₂ , Maria Giovanna Quaranta ₁ , Laura Gragnani ₂ , Valentina Panetta ₃ , Giuseppina Brancaccio ₄ , Cesare Mazzaro ₅ , Marcello Persico ₆ , Mario Masarone ₆ , Ivan Gentile ₇ , Pietro Andreone ₈ , Salvatore Madonia ₉ , Elisa Biliotti ₁₀ , Roberto Filomia ₁₁ , Massimo Puoti ₁₂ , Anna Ludovica Fracanzani ₁₃ , Diletta Laccabue ₁₄ , Donatella Ieluzzi ₁₅ , Carmine Coppola ₁₆ , Maria Grazia Rumi ₁₇ , Antonio Benedetti ₁₈ , Gabriella Verucchi ₁₉ , Barbara Coco ₂₀ , Liliana Chemello ₂₁ , Andrea Iannone ₂₂ , Alessia Ciancio ₂₃ , Francesco Paolo Russo ₂₄ , Francesco Barbaro ₂₅ , Filomena Morisco ₂₆ , Luchino Chessa ₂₇ , Marco Massari ₂₈ , Pierluigi Blanc ₂₉ , Anna Linda Zignego ₂

Affiliation

Center for Global Health, Istituto Superiore di Sanità, Rome, Italy.
Center for Systemic Manifestations of Hepatitis Viruses, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
L'altrastatistica srl, Consultancy & Training, Biostatistics office, Rome, Italy.
Department of Molecular Medicine, Infectious Diseases, University of Padua, Padua, Italy.
Clinical and Experimental Onco-Haematology Unit, IRCCS Centro di Riferimento Oncologico, Aviano, Pordenone, Italy.
Internal Medicine and Hepatology Unit, Salerno University, Salerno, Italy.
Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy.
Department of Internal Medicine, Villa Sofia-Cervello Hospital, Palermo, Italy.
Infectious and Tropical Diseases Unit, Umberto I Hospital-"Sapienza" University, Rome, Italy.
Department of Internal Medicine, University Hospital of Messina, Messina, Italy.
Infectious Diseases Unit, Niguarda Hospital, Milan, Italy.
General Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy.
Laboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, University of Parma, Parma, Italy.
Liver Unit, University Hospital of Verona, Verona, Italy.
Department of Hepatology, Gragnano Hospital, Gragnano, Naples, Italy.
Hepatology Unit, San Giuseppe Hospital, Milan, Italy.
Clinic of Gastroenterology and Hepatology, Università Politecnica delle Marche, Ancona, Italy.
Clinic of Infectious Diseases and Microbiology Unit, Alma Mater Studiorum Bologna University, Bologna, Italy.
Hepatology and Liver Physiopathology Laboratory and Internal Medicine, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy.
Unit of Internal Medicine and Hepatology-Clinica Medica 5, Department of Medicine-DIMED, University of Padua, Padua, Italy.
Gastroenterology Unit, University of Bari, Bari, Italy.
Gastroenterology Unit, Città della Salute e della Scienza of Turin, University Hospital, Turin, Italy.
Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.
Infectious and Tropical Diseases Unit, University of Padua, Padua, Italy.
Gastroenterology Unit, Federico II University, Naples, Italy.
Liver Unit, University of Cagliari, Cagliari, Italy.
Infectious Diseases Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Infectious Disease Unit, Santa Maria Annunziata Hospital, Florence, Italy.

Mixed cryoglobulinemia is the most common HCV extrahepatic manifestation. We aimed to prospectively evaluate the cryoglobulinemic vasculitis (CV) clinical profile after a sustained virologic response (SVR) over a medium-term to long-term period.

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