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Laccase-mediated oxidation of steroid alcohols in the presence of methylated β-cyclodextrin: from inhibition to selective synthesis
Journal of Chemical Technology and Biotechnology ( IF 2.8 ) Pub Date : 2021-12-01 , DOI: 10.1002/jctb.7000
Sergey M. Khomutov 1 , Andrey A. Shutov 1 , Aleksey D. Averin 2 , Dmitry V. Dovbnya 1 , Marina V. Donova 1
Affiliation  

Laccase mediator systems (LMS) possess great potential in organic synthesis for selective oxidation in mild conditions. However, their usage in steroid synthetic chemistry is limited by low aqueous solubility of the substrates. In this study, the effect of steroid complexation with methylated cyclodextrin (mCD) on LMS oxidation has been studied.

中文翻译:

甲基化β-环糊精存在下漆酶介导的甾醇氧化:从抑制到选择性合成

漆酶介体系统(LMS)在温和条件下选择性氧化的有机合成中具有巨大潜力。然而,它们在类固醇合成化学中的使用受到底物低水溶性的限制。在本研究中,研究了类固醇与甲基化环糊精 (mCD) 络合对 LMS 氧化的影响。
更新日期:2021-12-01
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