Background. Atrial fibrillation (AF) is a common, sustained cardiac arrhythmia. Recent studies have reported an association between ZFHX3/PRRX1 polymorphisms and AF. In this study, a meta-analysis was conducted to confirm these associations. Objective and Methods. The PubMed, Embase, and Wanfang databases were searched, covering all publications before July 20, 2020. Results. Overall, seven articles including 3,674 cases and 8,990 healthy controls for ZFHX3 rs2106261 and 1045 cases and 1407 controls for PRRX1 rs3903239 were included. The odds ratio (OR) (95% confidence interval (CI)) was used to assess the associations. Publication bias was calculated using Egger’s and Begg’s tests. We found that the ZFHX3 rs2106261 polymorphism increased AF risk in Asians (for example, allelic contrast: OR [95% CI]: 1.39 [1.31–1.47], ). Similarly, strong associations were detected through stratified analysis using source of control and genotype methods (for example, allelic contrast: OR [95% CI]: 1.51 [1.38–1.64], for HB; OR [95% CI]: 1.31 [1.21–1.41], for PB; OR [95% CI]: 1.55 [1.33–1.80], for TaqMan; and OR [95% CI]: 1.31 [1.21–1.41], for high-resolution melt). In contrast, an inverse relationship was observed between the PRRX1 rs3903239 polymorphism and AF risk (C-allele vs. T-allele: OR [95% CI]: 0.83 [0.77–0.99], ; CT vs. TT: OR [95% CI]: 0.79 [0.67–0.94], ). No obvious evidence of publication bias was observed. Conclusions. In summary, our study suggests that the ZFHX3 rs2106261 and PRRX1 rs3903239 polymorphisms are associated with AF risk, and larger case-controls must be carried out to confirm the abovementioned conclusions.

中文翻译：

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荟萃分析 ZFHX3 和 PRRX1 多态性与心房颤动易感性之间的关联

背景。心房颤动 (AF) 是一种常见的持续性心律失常。最近的研究报告了 ZFHX3/PRRX1 多态性与 AF 之间的关联。在这项研究中，进行了一项荟萃分析以确认这些关联。目的和方法。检索了 PubMed、Embase 和万方数据库，涵盖了 2020 年 7 月 20 日之前的所有出版物。结果. 总体而言，包括 7 篇文章，包括 ZFHX3 rs2106261 的 3,674 例和 8,990 例健康对照以及 PRRX1 rs3903239 的 1045 例和 1407 例对照。优势比 (OR) (95% 置信区间 (CI)) 用于评估相关性。使用 Egger 和 Begg 检验计算发表偏倚。我们发现 ZFHX3 rs2106261 多态性增加了亚洲人的 AF 风险（例如，等位基因对比：OR [95% CI]：1.39 [1.31–1.47]，）。同样，通过使用控制源和基因型方法的分层分析检测到强关联（例如，等位基因对比：OR [95% CI]：1.51 [1.38–1.64]，对于 HB；或 [95% CI]：1.31 [1.21–1.41]，用于铅；或 [95% CI]：1.55 [1.33–1.80]，对于 TaqMan；或 [95% CI]：1.31 [1.21–1.41]，用于高分辨率熔体）。相反，在 PRRX1 rs3903239 多态性和 AF 风险之间观察到负相关（C 等位基因与T 等位基因：OR [95% CI]：0.83 [0.77–0.99]，; CT与TT：或 [95% CI]：0.79 [0.67–0.94]，）。没有观察到发表偏倚的明显证据。结论。总之，我们的研究表明 ZFHX3 rs2106261 和 PRRX1 rs3903239 多态性与 AF 风险相关，必须进行更大的病例对照以证实上述结论。