Fluorinated Ionic Liquid Based Multicolor 19F MRI Nanoprobes for In Vivo Sensing of Multiple Biological Targets,Advanced Healthcare Materials

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Fluorinated Ionic Liquid Based Multicolor 19F MRI Nanoprobes for In Vivo Sensing of Multiple Biological Targets
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2021-12-13 , DOI: 10.1002/adhm.202102079
Xianglong Zhu _{1,

2} , Hehe Xiong ₂ , Sitian Wang ₂ , Yanyan Li ₂ , Jingxian Chi ₂ , Xuefei Wang ₂ , Tiantian Li ₂ , Qiuju Zhou ₂ , Jinhao Gao ₃ , Saige Shi _{1,

2}

Affiliation

Multicolor imaging, which maps the distribution of different targets, is important for in vivo molecular imaging and clinical diagnosis. Fluorine 19 magnetic resonance imaging (¹⁹F MRI) is a promising technique because of unique insights without endogenous background or tissue penetration limit. Thus multicolor ¹⁹F MRI probes, which can sense a wide variety of molecular species, are expected to help elucidate the biomolecular networks in complex biological systems. Here, a versatile model of activatable probes based on fluorinated ionic liquids (ILs) for multicolor ¹⁹F MRI is reported. Three types of ILs at different chemical shifts are loaded in nanocarriers and sealed by three stimuli-sensitive copolymers, leading to “off” ¹⁹F signals. The coating polymers specifically respond to their environmental stimuli, then degrade to release the loaded ILs, causing ¹⁹F signals recovery. The nanoprobes are utilized for non-invasive detection of tumor hallmarks, which are distinguished by their individual colors in one living mouse, without interference between each other. This multicolor imaging strategy, which adopts modular construction of various ILs and stimuli-responsive polymers, will allow more comprehensive sensing of multiple biological targets, thus, opening a new realm in mechanistic understanding of complex pathophysiologic processes in vivo.

中文翻译：

基于氟化离子液体的多色 19F MRI 纳米探针用于体内多生物目标的传感

多色成像可绘制不同靶点的分布图，对于体内分子成像和临床诊断非常重要。氟 19 磁共振成像 ( ¹⁹ F MRI) 是一种很有前途的技术，因为它具有独特的洞察力，没有内源性背景或组织穿透限制。因此，可以感知多种分子种类的多色^{19 F MRI 探针有望帮助阐明复杂生物系统中的生物分子网络。}^{本文报道了一种用于多色19} F MRI 的基于氟化离子液体 (IL) 的可激活探针的多功能模型。三种不同化学位移的离子液体被装载在纳米载体中，并由三种刺激敏感的共聚物密封，导致“关闭” ¹⁹F 信号。涂层聚合物对其环境刺激有特异性反应，然后降解以释放负载的 IL，导致¹⁹ F 信号恢复。纳米探针用于非侵入性检测肿瘤标志物，这些标志物在一只活体小鼠中通过它们各自的颜色来区分，彼此之间没有干扰。这种多色成像策略采用各种 IL 和刺激响应聚合物的模块化结构，将允许更全面地感知多个生物靶标，从而为体内复杂病理生理过程的机械理解开辟了一个新领域。

更新日期：2021-12-13

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