Hepatocyte transplantation holds great promise as an alternative approach to whole-organ transplantation. Intraportal and intrasplenic cell infusions are primary hepatocyte transplantation delivery routes for this procedure. However, patients with severe liver diseases often have disrupted liver and spleen architectures, which introduce risks in the engraftment process. We previously demonstrated i.p. injection of hepatocytes as an alternative route of delivery that could benefit this subpopulation of patients, particularly if less invasive and low-risk procedures are required; and we have established that lymph nodes may serve as extrahepatic sites for hepatocyte engraftment. However, whether other niches in the abdominal cavity support the survival and proliferation of the transplanted hepatocytes remains unclear.

中文翻译：

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脂肪相关淋巴团作为异位肝脏发育的可扩展生态位

肝细胞移植作为全器官移植的替代方法具有很大的前景。门静脉内和脾内细胞输注是该程序的主要肝细胞移植递送途径。然而，患有严重肝病的患者通常会破坏肝脏和脾脏的结构，这会在植入过程中带来风险。我们之前证明了腹腔内注射肝细胞作为一种替代递送途径，可以使这一亚群患者受益，特别是在需要侵入性较小和风险较低的手术时；我们已经确定淋巴结可以作为肝细胞移植的肝外部位。然而，腹腔中的其他生态位是否支持移植肝细胞的存活和增殖仍不清楚。