The ambient PM_2.5-related health burden (all-cause and cause-specific mortality, and years of life lost (YLL)) and its economic impacts in Isfahan during the period 2016–2019 were assessed. Ambient PM_2.5-related premature deaths were estimated using the Environmental Benefits Mapping and Analysis Program based on the most common global function, called the Global Exposure Mortality Model. The annual PM_2.5 concentrations in Isfahan was measured to be approximately six times higher (27.8–32.1 μg m⁻³) than the recommended by the World Health Organization value (5 μg/m³). Ambient PM_2.5-related all-cause mortality in Isfahan was in the range of 1311–1456 over the four-year period. Moreover, approximately 15% of all-cause mortality in adults (age 25 and above) was attributed to ambient PM_2.5 in Isfahan. Ischemic heart disease and stroke caused about 63% of PM_2.5-related total deaths in the city. The YLL attributable to ambient PM_2.5 exposures ranged from 22,488 to 25,614. The results demonstrated that avoided annual economic costs associated with reducing PM_2.5 ranged from $526,008,055 to $599,945,966 over the study period. The corresponding results for mortality, morbidity, and economic results would provide a measurable assessment to the policymakers of the city of Isfahan in order to intensify their efforts on improvement the ambient air quality.

评估了 2016 年至 2019 年期间伊斯法罕的环境 PM _2.5相关健康负担（全因和特定原因死亡率，以及生命损失年数 (YLL)）及其经济影响。使用环境效益绘图和分析程序基于最常见的全球函数（称为全球暴露死亡率模型）估计与环境 PM _2.5相关的过早死亡。伊斯法罕的年度 PM _2.5浓度经测量约为世界卫生组织推荐值（5 μg/m ³）的六倍（27.8–32.1 μg m ^-3）。环境 PM _2.5四年期间，伊斯法罕的相关全因死亡率在 1311-1456 之间。此外，在伊斯法罕，大约 15% 的成年人（25 岁及以上）全因死亡率归因于环境 PM _2.5。在该市与 PM _2.5相关的总死亡人数中，约有 63% 是由缺血性心脏病和中风引起的。可归因于环境 PM _2.5暴露的 YLL范围为 22,488 至 25,614。结果表明，可避免与降低 PM _2.5相关的年度经济成本在研究期间，从 526,008,055 美元到 599,945,966 美元不等。死亡率、发病率和经济结果的相应结果将为伊斯法罕市的决策者提供可衡量的评估，以加强他们改善环境空气质量的努力。