PURPOSE/OBJECTIVE To examine health-related quality of life (HR-QOL) in Veterans with and without a history of mild traumatic brain injury (mTBI) and investigate correlates and predictors of HR-QOL within the mTBI sample. Research Method/Design: Participants (N = 144) included 81 Veterans with a history of mTBI and 63 Veteran controls (VCs) without a history of mTBI. Primary outcomes of interest were the 8 subscales of the 36-Item Short Form Survey (SF-36). Participants also completed questionnaires measuring combat exposure, depressive and posttraumatic stress disorder (PTSD) symptoms, and neurobehavioral symptoms. RESULTS ANCOVAs adjusting for age found that, relative to VCs, the mTBI group demonstrated poorer HR-QOL across all SF-36 subscales (p's = ≤.001-.006; ηp² = .05-.21). After adjusting for age, combat exposure, and depressive and PTSD symptoms, the mTBI group endorsed poorer HR-QOL on the Physical Role Functioning, General Health, and Social Functioning subscales (p's = .011-.032; ηp² = .03-.05). Within the mTBI sample, employment status, lifetime number of mTBIs, depression, PTSD, and neurobehavioral symptoms collectively predicted all 8 SF-36 subscales (p's < .001), accounting for 29-65% of the total variance. Although depression and neurobehavioral symptoms tended to be the strongest predictors of HR-QOL, lifetime number of mTBIs and employment status were also important predictors of specific HR-QOL domains. CONCLUSIONS Results suggest that, above and beyond depression, PTSD, and combat exposure, history of remote mTBI contributes to aspects of HR-QOL-particularly in perceptions of physical health and social functioning. Furthermore, different combinations of predictor variables are associated with different HR-QOL domains, highlighting the need for multimodal treatments within this vulnerable population. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译：

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预测轻度创伤性脑损伤后退伍军人健康相关的生活质量。

目的/目的检查有和没有轻度创伤性脑损伤 (mTBI) 病史的退伍军人的健康相关生活质量 (HR-QOL)，并调查 mTBI 样本中 HR-QOL 的相关性和预测因素。研究方法/设计：参与者 (N = 144) 包括 81 名有 mTBI 病史的退伍军人和 63 名没有 mTBI 病史的退伍军人对照 (VC)。感兴趣的主要结果是 36 项简表调查 (SF-36) 的 8 个分量表。参与者还完成了测量战斗暴露、抑郁和创伤后应激障碍 (PTSD) 症状以及神经行为症状的问卷。结果 调整年龄的 ANCOVA 发现，相对于 VC，mTBI 组在所有 SF-36 分量表中表现出较差的 HR-QOL（p's = ≤.001-.006；ηp² = .05-.21）。调整年龄、战斗暴露后，以及抑郁和 PTSD 症状，mTBI 小组认可在身体角色功能、一般健康和社会功能分量表上的 HR-QOL 较差（p's = .011-.032；ηp² = .03-.05）。在 mTBI 样本中，就业状况、终生 mTBI 数量、抑郁症、PTSD 和神经行为症状共同预测了所有 8 个 SF-36 分量表 (p < .001)，占总方差的 29-65%。尽管抑郁症和神经行为症状往往是 HR-QOL 的最强预测因子，但终生 mTBIs 数量和就业状况也是特定 HR-QOL 领域的重要预测因子。结论 结果表明，除了抑郁症、创伤后应激障碍和战斗暴露之外，远程 mTBI 的历史有助于 HR-QOL 的各个方面，尤其是对身体健康和社会功能的看法。此外，预测变量的不同组合与不同的 HR-QOL 领域相关，突出了在这个脆弱人群中进行多模式治疗的必要性。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。