The burden of end-stage osteoarthritis in Australia: a population-based study on the incidence of total knee replacement attributable to overweight/obesity,Osteoarthritis and Cartilage

当前位置： X-MOL 学术 › Osteoarthr. Cartil. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

The burden of end-stage osteoarthritis in Australia: a population-based study on the incidence of total knee replacement attributable to overweight/obesity
Osteoarthritis and Cartilage ( IF 7.2 ) Pub Date : 2021-12-07 , DOI: 10.1016/j.joca.2021.10.017
L Chen ₁ , M Zheng ₂ , Z Chen ₁ , Y Peng ₃ , C Jones ₄ , S Graves ₅ , P Chen ₁ , R Ruan ₁ , J Papadimitriou ₆ , R Carey-Smith ₇ , T Leys ₇ , C Mitchell ₁ , Y G Huang ₈ , D Wood ₁ , M Bulsara ₂ , M H Zheng ₉

Affiliation

Centre for Translational Orthopaedic Research, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia.
Institute for Health Research, Medical School, University of Notre Dame Australia, Fremantle, Western Australia, Australia.
South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia; Australian Orthopaedic Association National Joint Replacement Registry, Adelaide, South Australia, Australia.
Department of Orthopaedic Surgery, Fiona Stanley Hospital Group, Perth, Western Australia, Australia.
Australian Orthopaedic Association National Joint Replacement Registry, Adelaide, South Australia, Australia.
Centre for Translational Orthopaedic Research, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia; Pathwest Laboratories, Perth, Western Australia, Australia.
Department of Orthopaedic Surgery, Sir Charles Gardner Hospital, Perth, Western Australia, Australia.
Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Centre for Translational Orthopaedic Research, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia; Perron Institute for Neurological and Translational Science, Perth, Western Australia, Australia.

Objectives

To determine the risk of total knee replacement (TKR) for primary osteoarthritis (OA) associated with overweight/obesity in the Australian population.

Methods

This population-based study analyzed 191,723 cases of TKR collected by the Australian Orthopaedic Association National Joint Registry and population data from the Australian Bureau of Statistics. The time-trend change in incidence of TKR relating to BMI was assessed between 2015 and 2018. The influence of obesity on the incidence of TKR in different age and gender groups was determined. The population attributable fraction (PAF) was then calculated to estimate the effect of obesity reduction on TKR incidence.

Results

The greatest increase in incidence of TKR was seen in patients from obese class III. The incidence rate ratio for having a TKR for obesity class III was 28.683 at those aged 18–54 years but was 2.029 at those aged >75 years. Females in obesity class III were 1.7 times more likely to undergo TKR compared to similarly classified males. The PAFs of TKR associated with overweight or obesity was 35%, estimating 14,287 cases of TKR attributable to obesity in 2018. The proportion of TKRs could be reduced by 20% if overweight and obese population move down one category.

Conclusions

Obesity has resulted in a significant increase in the incidence of TKR in the youngest population in Australia. The impact of obesity is greatest in the young and the female population. Effective strategies to reduce the national obese population could potentially reduce 35% of the TKR, with over 10,000 cases being avoided.

中文翻译：

澳大利亚终末期骨关节炎的负担：一项基于人群的超重/肥胖导致的全膝关节置换发生率研究

目标

确定全膝关节置换术 (TKR) 治疗澳大利亚人群中与超重/肥胖相关的原发性骨关节炎 (OA) 的风险。

方法

这项基于人群的研究分析了澳大利亚骨科协会全国联合登记处收集的 191,723 例 TKR 病例和澳大利亚统计局的人口数据。评估了 2015 年至 2018 年间与 BMI 相关的 TKR 发生率的时间趋势变化。确定了肥胖对不同年龄和性别组 TKR 发生率的影响。然后计算人口归因分数 (PAF) 以估计肥胖减少对 TKR 发生率的影响。

结果

在肥胖 III 级患者中观察到 TKR 发生率的最大增加。18-54 岁的肥胖 III 级 TKR 的发病率比为 28.683，而年龄>75 岁的为 2.029。与同样分类的男性相比，肥胖 III 级的女性接受 TKR 的可能性高 1.7 倍。与超重或肥胖相关的 TKR 的 PAF 为 35%，估计 2018 年有 14,287 例归因于肥胖的 TKR。如果超重和肥胖人群下降一个类别，TKR 的比例可降低 20%。