Colorectal cancer (CRC) develops and progresses in a nutritional environment comprising a continuously changing luminal cocktail of external dietary and microbial factors on the apical side, and a dynamic host-related pool of systemic factors on the serosal side. In this review, we highlight how this two-front environment influences the bioenergetic status of colonocytes throughout CRC development from (cancer) stem cells to cancer cells in nutrient-rich and nutrient-poor conditions, and eventually to metastatic cells, which, upon entry to the circulation and during metastatic seeding, are forced to metabolically adapt. Furthermore, given the influence of diet on the two-front nutritional environment, we discuss dietary strategies that target the specific metabolic preferences of these cells, with a possible impact on colon cancer cell bioenergetics and CRC outcome.

结直肠癌 (CRC) 在营养环境中发展和发展，该环境包括顶端侧不断变化的外部饮食和微生物因子的管腔混合物，以及浆膜侧的动态宿主相关系统因子库。在这篇综述中，我们强调了这两种前线环境如何影响结肠细胞在整个 CRC 发育过程中的生物能量状态，从（癌症）干细胞到营养丰富和营养缺乏条件下的癌细胞，并最终转化为转移细胞，这些细胞在进入时循环和转移播种期间，被迫代谢适应。此外，鉴于饮食对两方面营养环境的影响，我们讨论了针对这些细胞特定代谢偏好的饮食策略，