Abstract

Silver nanoparticles (AgNPs) have big potentials in designing next-generation anticancer and antimicrobial agents. Here, AgNPs were synthesized with green chemistry using edible mushrooms Schizophyllum commune and Geopora sumneriana. The synthesized AgNPs were characterized with ultraviolet-visible spectrophotometry (UV–Vis), Fourier transform infrared spectrophotometer (FTIR), scanning transmission electron microscope (S-TEM), energy dispersive spectrometry (EDS), x-ray diffraction (XRD), and dynamic light scattering (DLS) techniques. Anticancer activities of the synthesized S. commune (SC-AgNPs) and G. sumneriana (GS-AgNPs) were studied on the breast (MCF-7), lung (A549), colon (HT-29), and liver (HUH-7) cancer cell lines. Also, the antimicrobial potential of SC-AgNPs and GS-AgNPs was determined against pathogens bacteria (Pseudomonas aeruginosa, Klebsiella pneumonia, Staphylococcus aureus, and Enterococcus faecalis) and fungal (Candida albicans and Candida utilis) strains. Obtained results demonstrated that the synthesized SC-AgNPs and GS-AgNPs have anticancer and antimicrobial activity. Our study implicates that SC-AgNPs and GS-AgNPs have great potentials for the treatment of cancer and infectious diseases.

摘要

银纳米粒子 (AgNPs) 在设计下一代抗癌和抗菌剂方面具有巨大潜力。在这里，使用食用菌Schizophyllum commune和Geopora sumneriana 用绿色化学合成了 AgNPs。采用紫外-可见分光光度法 (UV-Vis)、傅里叶变换红外分光光度计 (FTIR)、扫描透射电子显微镜 (S-TEM)、能量色散光谱法 (EDS)、X 射线衍射 (XRD) 和动态光散射（DLS）技术。合成的S. commune (SC-AgNPs) 和G. sumneriana的抗癌活性(GS-AgNPs) 在乳腺癌 (MCF-7)、肺癌 (A549)、结肠 (HT-29) 和肝癌 (HUH-7) 癌细胞系上进行了研究。此外，还测定了 SC-AgNPs 和 GS-AgNPs 对病原体细菌（铜绿假单胞菌、肺炎克雷伯菌、金黄色葡萄球菌和粪肠球菌）和真菌（白色念珠菌和产朊假丝酵母）菌株的抗菌潜力。获得的结果表明，合成的 SC-AgNPs 和 GS-AgNPs 具有抗癌和抗菌活性。我们的研究表明，SC-AgNPs 和 GS-AgNPs 在治疗癌症和传染病方面具有巨大潜力。