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Green synthesis of silver nanoparticles using Schizophyllum commune and Geopora sumneriana extracts and evaluation of their anticancer and antimicrobial activities
Particulate Science and Technology ( IF 2.3 ) Pub Date : 2021-12-06 , DOI: 10.1080/02726351.2021.2010846
Nazan Gökşen Tosun 1 , Özlem Kaplan 2 , İbrahim Türkekul 3 , İsa Gökçe 4 , Aykut Özgür 5
Affiliation  

Abstract

Silver nanoparticles (AgNPs) have big potentials in designing next-generation anticancer and antimicrobial agents. Here, AgNPs were synthesized with green chemistry using edible mushrooms Schizophyllum commune and Geopora sumneriana. The synthesized AgNPs were characterized with ultraviolet-visible spectrophotometry (UV–Vis), Fourier transform infrared spectrophotometer (FTIR), scanning transmission electron microscope (S-TEM), energy dispersive spectrometry (EDS), x-ray diffraction (XRD), and dynamic light scattering (DLS) techniques. Anticancer activities of the synthesized S. commune (SC-AgNPs) and G. sumneriana (GS-AgNPs) were studied on the breast (MCF-7), lung (A549), colon (HT-29), and liver (HUH-7) cancer cell lines. Also, the antimicrobial potential of SC-AgNPs and GS-AgNPs was determined against pathogens bacteria (Pseudomonas aeruginosa, Klebsiella pneumonia, Staphylococcus aureus, and Enterococcus faecalis) and fungal (Candida albicans and Candida utilis) strains. Obtained results demonstrated that the synthesized SC-AgNPs and GS-AgNPs have anticancer and antimicrobial activity. Our study implicates that SC-AgNPs and GS-AgNPs have great potentials for the treatment of cancer and infectious diseases.



中文翻译:

用裂叶菌和地孔菌提取物绿色合成银纳米颗粒及其抗癌和抗菌活性评价

摘要

银纳米粒子 (AgNPs) 在设计下一代抗癌和抗菌剂方面具有巨大潜力。在这里,使用食用菌Schizophyllum communeGeopora sumneriana 用绿色化学合成了 AgNPs。采用紫外-可见分光光度法 (UV-Vis)、傅里叶变换红外分光光度计 (FTIR)、扫描透射电子显微镜 (S-TEM)、能量色散光谱法 (EDS)、X 射线衍射 (XRD) 和动态光散射(DLS)技术。合成的S. commune (SC-AgNPs) 和G. sumneriana的抗癌活性(GS-AgNPs) 在乳腺癌 (MCF-7)、肺癌 (A549)、结肠 (HT-29) 和肝癌 (HUH-7) 癌细胞系上进行了研究。此外,还测定了 SC-AgNPs 和 GS-AgNPs 对病原体细菌(铜绿假单胞菌肺炎克雷伯菌金黄色葡萄球菌粪肠球菌)和真菌(白色念珠菌和产朊假丝酵母)菌株的抗菌潜力。获得的结果表明,合成的 SC-AgNPs 和 GS-AgNPs 具有抗癌和抗菌活性。我们的研究表明,SC-AgNPs 和 GS-AgNPs 在治疗癌症和传染病方面具有巨大潜力。

更新日期:2021-12-06
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