It is estimated that 25–30 per cent of RCTs fail to reach their target sample size. Multicentre design, publication year, and commercial sponsor were inversely associated with failure to reach the target sample size. A substantial proportion of surgical trials fail reach target sample size, but the trend is showing improvement.

中文翻译：

---

手术随机试验中未能达到目标样本量的预测因素

据估计，25-30% 的随机对照试验未能达到目标样本量。多中心设计、出版年份和商业赞助商与未能达到目标样本量呈负相关。很大一部分手术试验未能达到目标样本量，但趋势正在改善。